Short-Acting P2Y12 Blockade to Reduce Platelet Dysfunction and Coagulopathy During Experimental Extracorporeal Circulation and Hypothermia
This experimental study tested P(2)Y(12) receptor blockade as an approach to protect platelets during ECC.
Systemic Inflammatory Response Syndrome after Extracorporeal Circulation: A Predictive Algorithm for the Patient at Risk
The results suggest a new theory regarding the development of perioperative SIRS.
A Review of Postoperative Cognitive Dysfunction and Neuroinflammation Associated with Cardiac Surgery and Anaesthesia
We briefly discuss the evidence for cardiopulmonary bypass-related neuronal injuries in adult cardiac surgery patients, and review the evidence that immune priming is a key factor in the pathogenesis of cognitive dysfunction after cardiac surgery.
Are Right Ventricular Risk Scores Useful?
The use of risk scores failed to predict the need of RV support after LVAD.
Silent Brain Injury after Cardiac Surgery: A Review: Cognitive Dysfunction and Magnetic Resonance Imaging Diffusion-Weighted Imaging Findings
The appearance of cognitive dysfunction after cardiac surgery in the absence of focal neurologic signs, a poorly understood but potentially devastating complication, almost certainly results from procedure-related brain injury.
Right Ventricular Failure after Cardiac Surgery
Techniques for managing the pulmonary circulation and strategies for optimizing RV function in various clinical settings are presented.
The Optimal Flow Rate for Antegrade Cerebral Perfusion During Deep Hypothermic Circulatory Arrest
Cerebral protection effects of ACP at 25 and 50 mL/kg/min were superior to that of ACP at 80 mL/kg/min as determined by cerebral markers, immunology, and histology.
Low-Flow Antegrade Cerebral Perfusion Attenuates Early Renal and Intestinal Injury During Neonatal Aortic Arch Reconstruction
These results substantiate earlier suggestions that ACP provides more abdominal organ protection than DHCA in neonates undergoing aortic arch reconstruction.
Population Pharmacokinetics of Olprinone in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass
Therefore, the purpose of this study was to determine olprinone pharmacokinetic parameters in a large population undergoing cardiac surgery with CPB.
Cerebral Protection during Controlled Hypoperfusion in a Piglet Model: Comparison of Moderate (25°C) versus Deep (18°C) Hypothermia at Various Flow Rates Using Intraoperative Measurements and Ex Vivo Investigation
The aim of this study was to evaluate the effectiveness and safety of controlled cerebral hypoperfusion at moderate (25°C) versus deep (18°C) hypothermia.
Plutonium-238: An Ideal Power Source for Intracorporeal Ventricular Assist Devices?
Ventricular assist devices emerged as a widely used modality for treatment of end-stage heart failure; however, despite significant advances, external energy supply remains a problem contributing to significant patient morbidity and potential mortality.
Central Venous Oxygen Saturation During Cardiopulmonary Bypass Predicts 3-Year Survival
The present report explores the connection between SvO2 during cardiopulmonary bypass (CPB) and survival after cardiac surgery.