Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis: the RESTORE Randomized Clinical Trial
Among patients with symptomatic mild to moderate radiographic knee OA, intra-articular injection of PRP, compared with injection of saline placebo, did not result in a significant difference in symptoms or joint structure at 12 months. These findings do not support use of PRP for the management of knee OA.
Intraoperative Collection of Autologous Platelet-Rich Plasma from The Cardiopulmonary Bypass Circuit Upon Initiation of Extracorporeal Circulation
Autologous PRP can be safely collected by drawing blood from the CPB circuit, platelet count and aggregation ability significantly decreased after CPB including autologous PRP collection. Some improvement was detected in the number of the platelets count and platelet aggregation ability by administrating an autologous PRP even if autologous PRP is collected from CPB circuit.
Laboratory Abnormalities in Patients with COVID-2019 Infection
The aim of this article is to provide a brief overview on the most frequent laboratory abnormalities encountered in patients with COVID-2019 infection.
Prominent Changes in Blood Coagulation of Patients with SARS-CoV-2 Infection
The coagulation function in patients with SARS-CoV-2 is significantly deranged compared with healthy people, but monitoring D-dimer and FDP values may be helpful for the early identification of severe cases.
Clinical Characteristics of Patients Who Died of Coronavirus Disease 2019 in China
The results of this case series show that only approximately one-fifth of patients who died of COVID-19 received invasive mechanical ventilation and further aggressive respiratory support prior to death, indicating that many patients had delayed intubation.
COVID-19: Consider Cytokine Storm Syndromes and Immunosuppression
We recommend identification and treatment of hyperinflammation using existing, approved therapies with proven safety profiles to address the immediate need to reduce the rising mortality.
Hemorrhagic Problem Among the Patients With COVID-19: Clinical Summary of 41 Thai Infected Patients
It is recommended that the practitioner should recognize that hemorrhagic problem might be an initial presentation of COVID-19. Also, investigation and follow-up for possible hemorrhagic problem in patient with COVID-19 is recommended.
Optimizing the Trade-off Between Learning and Doing in a Pandemic
There is a need to do (treat patients) and learn (test therapies) at the same time—they are intertwined endeavors. An integrated approach of learning while doing is essential.
CAPACITY-COVID: a European Registry to Determine the Role of Cardiovascular Disease in the COVID-19 Pandemic
To accelerate knowledge on the role of cardiovascular disease in the COVID-19 pandemic, standardized and coordinated data collection on a large scale is of pivotal importance.
High-Sensitivity Cardiac Troponin Can Be An Ally in the Fight Against COVID-19
Troponin should be considered an ally and a crucial diagnostic and prognostic aid in what will become even more challenging times for healthcare provision worldwide.
Current Practice of Calcium Use During Cardiopulmonary Bypass Weaning: Results of an International Survey
This survey demonstrates that the majority of cardiac centers use calcium in adult patients undergoing cardiac surgery, especially during weaning from CPB. There is variability on the type of drug, dose, and modality of drug administration.
The Impact of Circulation in a Heart–Lung Machine on Function and Survival Characteristics of Red Blood Cells
These changes in key characteristics of the red blood cell aging process likely increase the susceptibility of red blood cells to the various mechanical, osmotic, and immunological stress conditions encountered during and after surgery in the patient’s circulation, and thereby contribute to the side effects of surgery.