Intralipid, A Clinically Safe Compound, Protects the Heart against Ischemia-Reperfusion Injury more Efficiently than Cyclosporine-A
Here we compared the cardioprotective effects of intralipid with cyclosporine-A, a potent inhibitor of the mitochondrial permeability transition pore opening.
High Fidelity Case-Based Simulation Debriefing: Everything You Need to Know
In this 30-minute talk, the authors take an in-depth look at how to debrief high-fidelity case-based simulation sessions, including discussion on debriefing theory, goals, approaches, and structure, as well as ways to create a supportive and safe learning environment, resulting in successful small group learning and self-reflection.
Endogenous Hydrogen Sulfide Mediates the Cardioprotection Induced by Ischemic Postconditioning in the Early Reperfusion Phase
The present study aimed to investigate the role of H(2)S in ischemic postconditioning (IPO) during the early period of reperfusion.
Insensible Water Loss from the Hilite 2400LT Oxygenator: An In Vitro Study
The aim of this study is to explore the degree to which free water loss occurs across a commonly used ECMO oxygenator, the polymethylpentene (PMP) membrane Hilite(®) 2400LT (Medos, Medizintechnik AG, Stolberg, Germany).
Rapamycin Protects against Myocardial Ischemia-Reperfusion Injury through JAK2-STAT3 Signaling Pathway
We propose that rapamycin is a novel and clinically relevant pharmacological strategy to target STAT3 activation for treatment of myocardial infarction.
Cardioprotective Effect of Melatonin against Ischaemia/Reperfusion Damage
Melatonin, both in the picomolar and micromolar range, significantly reduces infarct size and improves functional recovery during reperfusion.
Left Atrial Appendage Occlusion and Ligation Devices: What is Available, How to Implement Them, and how to Manage and Avoid Complications
Surgical ligation or excision of the LAA is considered the standard of care in patients who undergo mitral valve surgery or as an adjunct to a surgical Maze procedure for treatment of AF.
Managing a Surgical Exsanguination Emergency in the Operating Room through Simulation: An Interdisciplinary Approach
Operating room (OR) emergencies, such as fire, anaphylaxis, cardiac arrest, and exsanguination, are infrequent, but high-risk situations that can result in significant morbidity and mortality.
The Use of ECMO for Persistent Pulmonary Hypertension of the Newborn: A Decade of Experience
The objectives of this study were to use the Extracorporeal Life Support Organization Registry to review the outcomes of neonates with PPHN receiving ECMO, and to identify pre-ECMO variables that may be associated with increased mortality.
A Thrombus Susceptibility Comparison of Two Pulsatile Penn State 50 cc Left Ventricular Assist Device Designs
Results of this study indicate that the V-2 device had an overall lower propensity for thrombus formation in the current region of interest.
Teaching Behaviors in the Cardiac Surgery Simulation Environment
To understand how teaching behaviors contribute to simulation-based learning, we used a 7-category educational framework to assess the teaching behaviors used in basic skills training.
Isoflurane Prevents Neurocognitive Dysfunction After Cardiopulmonary Bypass in Rats
Isoflurane has documented neuroprotective effects so the present authors hypothesized that isoflurane prevents the neurocognitive dysfunction in rats after CPB.