The Future:Therapy of Myocardial Protection
Recent studies have proposed that old, inexpensive drugs--in human use for decades (e.g., β-blockers and cyclosporine, among others)--can reduce ischemia/reperfusion injury, I/R injury, when administered intravenously before coronary opening. The demonstration of such a cardioprotective effect should have a significant impact in the care of AMI patients.
Perioperative Coagulation Management During Cardiac Surgery
Prospective randomized multicenter studies are needed to confirm the hypothesis that algorithm-based specific hemotherapy in conjunction with POC testing minimizes patient's exposure to blood products and improves clinical outcome.
Anaortic, Total-Arterial, Off-Pump Coronary Artery Bypass Surgery-Why Bother
Some recent trials comparing conventional on-pump CABG with OPCAB have questioned the efficacy of the off-pump technique - these are most often performed with manipulation of the ascending aorta. We review the potential benefits of the anaortic, total-arterial OPCAB technique to explain why it is being employed by an increasing number of surgeons.
Effects of Fibrinogen Concentrate as First-line Therapy during Major Aortic Replacement Surgery: A Randomized, Placebo-controlled Trial
Hemostatic therapy with fibrinogen concentrate in patients undergoing aortic surgery significantly reduced the transfusion of allogeneic blood products. Larger multicenter studies are necessary to confirm the role of fibrinogen concentrate in the management of perioperative bleeding in patients with life-threatening coagulopathy.
The Year in Cardiothoracic and Vascular Anesthesia: Selected Highlights from 2012
The year 2012 has witnessed the emergence of new paradigms of care in our specialty with the emphasis on teamwork, safety, and quality. These processes will further improve perioperative outcome.
Transfusion and Risk of Acute Kidney Injury in Cardiac Surgery
This narrative review focuses on the relationship between perioperative red blood cell transfusion and AKI after cardiac surgery with cardiopulmonary bypass (CPB).
Value of Internal Thoracic Artery Grafting to the Left Anterior Descending Coronary Artery at Coronary Reoperation
The study sought to determine if left internal thoracic artery (LITA) grafting of the left anterior descending (LAD) at reoperative coronary artery bypass grafting (CABG) improves patient outcomes.
Intralipid, A Clinically Safe Compound, Protects the Heart against Ischemia-Reperfusion Injury more Efficiently than Cyclosporine-A
Here we compared the cardioprotective effects of intralipid with cyclosporine-A, a potent inhibitor of the mitochondrial permeability transition pore opening.
High Fidelity Case-Based Simulation Debriefing: Everything You Need to Know
In this 30-minute talk, the authors take an in-depth look at how to debrief high-fidelity case-based simulation sessions, including discussion on debriefing theory, goals, approaches, and structure, as well as ways to create a supportive and safe learning environment, resulting in successful small group learning and self-reflection.
Endogenous Hydrogen Sulfide Mediates the Cardioprotection Induced by Ischemic Postconditioning in the Early Reperfusion Phase
The present study aimed to investigate the role of H(2)S in ischemic postconditioning (IPO) during the early period of reperfusion.
Insensible Water Loss from the Hilite 2400LT Oxygenator: An In Vitro Study
The aim of this study is to explore the degree to which free water loss occurs across a commonly used ECMO oxygenator, the polymethylpentene (PMP) membrane Hilite(®) 2400LT (Medos, Medizintechnik AG, Stolberg, Germany).
Rapamycin Protects against Myocardial Ischemia-Reperfusion Injury through JAK2-STAT3 Signaling Pathway
We propose that rapamycin is a novel and clinically relevant pharmacological strategy to target STAT3 activation for treatment of myocardial infarction.