Right Atrial Myxoma and Severe Left Ventricular Dysfunction: Which Explanations? Which Management?
A 57 year-old woman with a large right atrial myxoma underwent emergency surgical resection in our institute. It is known that surgical management of such tumours is difficult regarding venous cannulation and embolic risk, but in our patient, the surgery was more challenging because of the severe left ventricular dysfunction.
Cyclosporine A Normalizes Mitochondrial Coupling, Reactive Oxygen Species Production, and Inflammation and Partially Restores Skeletal Muscle Maximal Oxidative Capacity in Experimental Aortic Cross-Clamping
Cyclosporine A normalized ROS production, decreased inflammation, and restored mitochondrial coupling during aortic cross-clamping. Incomplete V(max) protection might be due to low cyclophilin D expression in gastrocnemius, preventing CsA from blocking mPTP opening.
Diabetes Clinical Trials: Helped or Hindered by the Current Shift in Regulatory Requirements
The potential for some agents to increase the risk of cardiovascular events has led to substantial changes in regulatory requirements for new anti-diabetic therapies. These requirements, while key to ensuring the cardiovascular safety of new agents, fail to emphasize the need to show clinical benefits, such as less visual impairment, less need for dialysis, or fewer cardiovascular events and deaths.
The Year in Cardiothoracic and Vascular Anesthesia: Selected Highlights from 2012
The year 2012 has witnessed the emergence of new paradigms of care in our specialty with the emphasis on teamwork, safety, and quality. These processes will further improve perioperative outcome.
Transfusion and Risk of Acute Kidney Injury in Cardiac Surgery
This narrative review focuses on the relationship between perioperative red blood cell transfusion and AKI after cardiac surgery with cardiopulmonary bypass (CPB).
Value of Internal Thoracic Artery Grafting to the Left Anterior Descending Coronary Artery at Coronary Reoperation
The study sought to determine if left internal thoracic artery (LITA) grafting of the left anterior descending (LAD) at reoperative coronary artery bypass grafting (CABG) improves patient outcomes.
Effects of Fibrinogen Concentrate as First-line Therapy during Major Aortic Replacement Surgery: A Randomized, Placebo-controlled Trial
Hemostatic therapy with fibrinogen concentrate in patients undergoing aortic surgery significantly reduced the transfusion of allogeneic blood products. Larger multicenter studies are necessary to confirm the role of fibrinogen concentrate in the management of perioperative bleeding in patients with life-threatening coagulopathy.
Endogenous Hydrogen Sulfide Mediates the Cardioprotection Induced by Ischemic Postconditioning in the Early Reperfusion Phase
The present study aimed to investigate the role of H(2)S in ischemic postconditioning (IPO) during the early period of reperfusion.
Insensible Water Loss from the Hilite 2400LT Oxygenator: An In Vitro Study
The aim of this study is to explore the degree to which free water loss occurs across a commonly used ECMO oxygenator, the polymethylpentene (PMP) membrane Hilite(®) 2400LT (Medos, Medizintechnik AG, Stolberg, Germany).
Rapamycin Protects against Myocardial Ischemia-Reperfusion Injury through JAK2-STAT3 Signaling Pathway
We propose that rapamycin is a novel and clinically relevant pharmacological strategy to target STAT3 activation for treatment of myocardial infarction.
Cardioprotective Effect of Melatonin against Ischaemia/Reperfusion Damage
Melatonin, both in the picomolar and micromolar range, significantly reduces infarct size and improves functional recovery during reperfusion.
Left Atrial Appendage Occlusion and Ligation Devices: What is Available, How to Implement Them, and how to Manage and Avoid Complications
Surgical ligation or excision of the LAA is considered the standard of care in patients who undergo mitral valve surgery or as an adjunct to a surgical Maze procedure for treatment of AF.