Effect of Processing and Storage on Red Blood Cell Function In Vivo
Red blood cell (RBC) transfusion is indicated to improve oxygen delivery to tissue, and for no other purpose.
Haemostatic Therapy in Coronary Artery Bypass Graft Patients with Decreased Platelet Function: Comparison of Fibrinogen Concentrate with Allogeneic Blood Products
Fibrinogen concentrate administration increased the fibrin clot quality and helped achieve haemostasis.
Effects of Magnesium Sulphate on Postoperative Coagulation, Measured by Rotational Thromboelastometry (ROTEM(®)).
Intra-operative infusion of magnesium sulphate seems to attenuate postoperative hypercoagulability by maintaining magnesium levels at the upper limit of the normal range.
Impact of Transfusion of Autologous 7- versus 42-Day-Old AS-3 Red Blood Cells on Tissue Oxygenation and the Microcirculation in Healthy Volunteers
Transfusion of 1 unit of 42-day-stored RBCs to healthy subjects has no overt detrimental effect on tissue oxygenation or the microcirculation assessed by clinically available monitors.
Decreased Coronary Microvascular Reactivity after Cardioplegic Arrest in Patients with Uncontrolled Diabetes Mellitus
Uncontrolled diabetes is associated with endothelium-dependent and -independent vascular dysfunction of coronary arterioles.
A Pilot Feasibility Trial of Allocation of Freshest Available Red Blood Cells versus Standard Care in Critically Ill Patients
We aimed to evaluate in intensive care unit (ICU) patients 1) the feasibility of allocating freshest available compatible RBCs versus standard care and 2) the suitability of this approach in the design of a large randomized controlled trial (RCT).
Prolonged Central Venous Desaturation Measured by Continuous Oximetry is Associated with Adverse Outcomes in Pediatric Cardiac Surgery
We demonstrate that ScvO₂ desaturations by continuous oximetry are associated with major adverse events in pediatric patients undergoing cardiac surgery.
Cell-Derived Microparticles in Stored Blood Products: Innocent-Bystanders or Effective Mediators of Post-Transfusion Reactions?
Plasma membrane-derived microvesicles or microparticles (MPs) are sub-cellular vesicles released upon shear stress, cell activation, injury or apoptosis.
Acute Neurological Complications after Pediatric Cardiac Surgery: Still a Long Way to Go
Our incidence of neurological complications after cardiac surgery is similar to that previously described.
The Efficacy of Parecoxib on Systemic Inflammatory Response Associated with Cardiopulmonary Bypass During Cardiac Surgery
Intraoperative parecoxib attenuated systemic inflammatory response associated with CPB during cardiac surgery and lowered the biochemical markers of myocardial injury.
Fenoldopam and Acute Renal Failure in Cardiac Surgery: A Meta-Analysis of Randomized Placebo-Controlled Trials
This analysis suggests that fenoldopam reduces acute kidney injury in patients undergoing cardiac surgery.
Microparticles from Stored Red Blood Cells Activate Neutrophils and Cause Lung Injury after Hemorrhage and Resuscitation
The presence of MPs in stored units can be associated with adverse effects, including lung injury, after transfusion.