Rapamycin Protects against Myocardial Ischemia-Reperfusion Injury through JAK2-STAT3 Signaling Pathway
We propose that rapamycin is a novel and clinically relevant pharmacological strategy to target STAT3 activation for treatment of myocardial infarction.
Left Atrial Appendage Occlusion and Ligation Devices: What is Available, How to Implement Them, and how to Manage and Avoid Complications
Surgical ligation or excision of the LAA is considered the standard of care in patients who undergo mitral valve surgery or as an adjunct to a surgical Maze procedure for treatment of AF.
Teaching Behaviors in the Cardiac Surgery Simulation Environment
To understand how teaching behaviors contribute to simulation-based learning, we used a 7-category educational framework to assess the teaching behaviors used in basic skills training.
Speaking up and Sharing Information Improves Trainee Neonatal Resuscitations
Teamwork behaviors of assertion and sharing information are 2 important mediators of efficiency and quality of resuscitations.
The Heparin Recall of 2008
This article will review the discovery of heparin and the adulteration process that jeopardized the world's heparin supply.
The Use of ECMO for Persistent Pulmonary Hypertension of the Newborn: A Decade of Experience
The objectives of this study were to use the Extracorporeal Life Support Organization Registry to review the outcomes of neonates with PPHN receiving ECMO, and to identify pre-ECMO variables that may be associated with increased mortality.
Speaking up is Related to Better Team Performance in Simulated Anesthesia Inductions: An Observational Study
This study provides empirical evidence and shows mechanisms for the positive relationship between speaking-up behavior and technical team performance.
Intralipid, A Clinically Safe Compound, Protects the Heart against Ischemia-Reperfusion Injury more Efficiently than Cyclosporine-A
Here we compared the cardioprotective effects of intralipid with cyclosporine-A, a potent inhibitor of the mitochondrial permeability transition pore opening.
Insensible Water Loss from the Hilite 2400LT Oxygenator: An In Vitro Study
The aim of this study is to explore the degree to which free water loss occurs across a commonly used ECMO oxygenator, the polymethylpentene (PMP) membrane Hilite(®) 2400LT (Medos, Medizintechnik AG, Stolberg, Germany).
Managing a Surgical Exsanguination Emergency in the Operating Room through Simulation: An Interdisciplinary Approach
Operating room (OR) emergencies, such as fire, anaphylaxis, cardiac arrest, and exsanguination, are infrequent, but high-risk situations that can result in significant morbidity and mortality.
Preconditioning Protects the Heart in a Prolonged Uremic Condition
We conclude that although prolonged experimental uremia leads to severe metabolic changes and the development of a mild myocardial dysfunction, the cardioprotective effect of ischemic preconditioning is still preserved.
Evolution of General Surgical Problems in Patients with Left Ventricular Assist Devices
Patients with LVADs frequently require consultation from noncardiac surgeons within the scope of general surgeons and often require operation.