A Review of Postoperative Cognitive Dysfunction and Neuroinflammation Associated with Cardiac Surgery and Anaesthesia
We briefly discuss the evidence for cardiopulmonary bypass-related neuronal injuries in adult cardiac surgery patients, and review the evidence that immune priming is a key factor in the pathogenesis of cognitive dysfunction after cardiac surgery.
Is it Worth Packing the Head with Ice in Patients Undergoing Deep Hypothermic Circulatory Arrest?
We conclude that topical head cooling with ice is of use during DHCA but not during rewarming following DHCA and that it may be possible to advance topical head cooling techniques using circulating water rather than packed ice.
Vasoreactivity Changes During Extracorporeal Circulation: Effects of Halogenated Agents
Absence of deleterious effects in SVR decrease when administering isoflurane during normothermic CPB was assumed but prospective comparative studies comparing effects of halogenated agents and other anesthetic agents are needed in order to confirm these findings.
Percutaneous Mechanical Support for the Failing Right Heart
This article considers the available mechanical approaches to provide hemodynamic support to treat profound RV failure in the common clinical scenarios in which percutaneous mechanical RV support may be most beneficial.
Right Ventricular Failure after Cardiac Surgery
Techniques for managing the pulmonary circulation and strategies for optimizing RV function in various clinical settings are presented.
A Modified Protocol for Retrograde Cerebral Perfusion: Magnetic Resonance Spectroscopy in Pigs
Application of the modified RCP protocol significantly improved cerebral energy conservation during HCA and accelerated energy recovery after rewarming.
The Optimal Flow Rate for Antegrade Cerebral Perfusion During Deep Hypothermic Circulatory Arrest
Cerebral protection effects of ACP at 25 and 50 mL/kg/min were superior to that of ACP at 80 mL/kg/min as determined by cerebral markers, immunology, and histology.
Clinical Efficacy of Intermittent Pressure Augmented-Retrograde Cerebral Perfusion
IPA-RCP might provide more homogenous cerebral perfusion and a more effective oxygen supply to the brain with better clinical results than conventional RCP.
The Volatile Anesthetic Sevoflurane Inhibits Activation of Neutrophil Granulocytes During Simulated Extracorporeal Circulation
Sevoflurane inhibits granulocyte activation during ex vivo ECC and therefore has the potential to decrease the ECC-triggered inflammatory response.
Are Right Ventricular Risk Scores Useful?
The use of risk scores failed to predict the need of RV support after LVAD.
Low-Flow Antegrade Cerebral Perfusion Attenuates Early Renal and Intestinal Injury During Neonatal Aortic Arch Reconstruction
These results substantiate earlier suggestions that ACP provides more abdominal organ protection than DHCA in neonates undergoing aortic arch reconstruction.
Short-Acting P2Y12 Blockade to Reduce Platelet Dysfunction and Coagulopathy During Experimental Extracorporeal Circulation and Hypothermia
This experimental study tested P(2)Y(12) receptor blockade as an approach to protect platelets during ECC.