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Intraoperative Off-Label Reversal of Apixaban by Andexanet Alfa while on VA-ECMO Immediately After Emergent Surgery for Acute Type A Aortic Dissection
There is currently no information available on either safety issues or efficacy related to the off-label use of andexanet alfa when given after prior administration of prothrombin complex concentrate, which has been discouraged so far, and in patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO).
When the Timing is Right: Antibiotic Timing and Infection After Cardiac Surgery
Guidelines recommend antibiotic prophylaxis 60 minutes before skin incision; however, it is unclear whether more precise timing would further reduce sternal wound infection. Our objectives were to examine the relationship between antibiotic timing and infection, test potential efficacy of optimal antibiotic timing in preventing infection, and determine whether patient comorbidity is related to timing and infection.
Strategies for Multivessel Revascularization in Patients with Diabetes
For patients with diabetes and advanced coronary artery disease, CABG was superior to PCI in that it significantly reduced rates of death and myocardial infarction, with a higher rate of stroke.