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Persistent Cognitive Deficits and Neuroinflammation In A Rat Model of Cardiopulmonary Bypass
By using an established rat model of CPB that does not display neuronal loss, we examined behavioral and structural effects of CPB at 6 months postsurgery. Persistent deficits in performance on a complex behavioral task and sustained activation of macrophages/microglia were observed with no evidence of neuronal loss.
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