Membrane Lung and Blood Pump Use During Prolonged Extracorporeal Membrane Oxygenation
This manuscript describes the use of membrane lungs and blood pumps used during ECLS support from 2002 to 2017 in over 65,000 patients reported to the Extracorporeal Life Support Organization Registry. Device longevity and complications associated with membrane lungs and blood pump are described and stratified by age group: neonates, pediatrics, and adults.
Switching to Centrifugal Pumps May Decrease Hemolysis Rates Among Pediatric ECMO Patients
These data suggest decreasing rates of hemolysis with centrifugal pumps compared to roller pumps. Since hemolysis was also associated with increased risk of death, these data support the switch from roller to centrifugal pumps at ECMO centers.
Effects of Implementing Rotational Thromboelastometry in Cardiac Surgery: A Retrospective Cohort Study
The use of thromboelastometry testing was associated with increased possibility to receive coagulation product transfusions. However, it appears that thromboelastometry testing was mostly used to assist in management of major bleeding.
CNS Complications in Adult Patients Treated With Extracorporeal Membrane Oxygenation
CNS complications appear to occur more frequently in patients requiring circulatory as opposed to respiratory support on extracorporeal membrane oxygenation and are independently associated with mortality. It remains unclear if these complications are causative of a poor outcome or a marker of severity of the underlying condition.
Cardiac Surgery Outcomes in an Epicenter of the COVID-19 Pandemic
The outcomes demonstrated herein suggest that with proper infection control, isolation, and patient selection, results similar to those observed in non-COVID series can be replicated.
Extension of Cardiopulmonary Bypass Outside the Operating Room as A Short-Term Bridge to Recovery “The Poor Man’s ECMO”
This report describes the use of conventional cardiopulmonary bypass (CPB) circuit beyond the operating room to the critical care unit to provide cardiopulmonary support for patients requiring emergent resuscitation as well as short-term support for rest and recovery of the heart.
Neural Network-Based Modeling of the Number of Microbubbles Generated with Four Circulation Factors in Cardiopulmonary Bypass
The study demonstrated the importance of four circulation factors in the prediction of the number of MBs and its capacity to eliminate potential postsurgical complication risks.
Cardiopulmonary Bypass-Induced Coagulopathy in Paediatric Patients: The Role of Platelets in Postoperative Bleeding. A Preliminary Study
Postoperative bleeding in children undergoing cardiac surgery with CPB was linked to younger age, longer CPB duration and significant postoperative reduction in platelet count and function. Larger studies are needed to confirm our results and define strategies to reduce postoperative bleeding in these patients.
Validation of Transcutaneous Carbon Dioxide Monitoring Using an Artificial Lung During Adult Pulsatile Cardiopulmonary Bypass
Our experience in utilizing tcCO2 during CPB has demonstrated accuracy in estimating PaCO2 when compared to the gold standard arterial blood gas analysis, even during CO2 flooding of the surgical field.
Dose Estimation for Bivalirudin during Pediatric Cardiopulmonary Bypass
Bivalirudin infusion in children should be started after loading dose at rates greater than those used in adults. Dose in neonates remains uncertain because neither pharmacokinetics nor coagulation pharmacodynamics have been adequately characterized.
Red Blood Cell Exosome Hemoglobin Content Increases After Cardiopulmonary Bypass and Mediates Acute Kidney Injury in an Animal Model
These combined studies raise the potential for RBC-derived Exos, released during CPB, to target the kidney and mediate AKI.
Molecular Cardioprotection and the Role of Exosomes: The Future Is Not Far Away
This review discusses anesthetic implications of exosome production and the future micro-RNA applications for cardioprotection.