Pregnancy in Marfan Syndrome After Aortic Root Replacement: A Case Report and Review of the Literature
Successful pregnancy and delivery can be achieved in Marfan's patients after aortic root replacement.
Medical Management of Thoracic Aortic Aneurysm Disease
Lifestyle modification is also important for patients with thoracic aortic aneurysm, including restrictions on physical activity, weight lifting, and recommendations about the management of pregnancy. Long-term surveillance of the aorta, even after successful surgery, is necessary for timing of prophylactic surgery and to evaluate for late complications.
Pregnancy Outcomes in Women with Aortic Valve Substitutes
Mechanical valve recipients had the greatest incidence of both cardiac and obstetric complications. In conclusion, pregnancy-associated complications after aortic valve replacement were common, and human tissue valves should be considered in the discussion for the optimal aortic valve substitute in a young woman. However, careful obstetric monitoring is mandatory.
Left-Right Ventricular Interactions in Pediatric Aortic Stenosis: Right Ventricular Myocardial Strain Before and After Aortic Valvuloplasty
Ventricular-ventricular interactions may affect left ventricular (LV) and right ventricular (RV) function but have not been well characterized in chronic LV afterload in children. The aim of this study was to assess RV myocardial strain in children with aortic stenosis before and after aortic balloon valvuloplasty.
The Future:Therapy of Myocardial Protection
Recent studies have proposed that old, inexpensive drugs--in human use for decades (e.g., β-blockers and cyclosporine, among others)--can reduce ischemia/reperfusion injury, I/R injury, when administered intravenously before coronary opening. The demonstration of such a cardioprotective effect should have a significant impact in the care of AMI patients.
Perioperative Coagulation Management During Cardiac Surgery
Prospective randomized multicenter studies are needed to confirm the hypothesis that algorithm-based specific hemotherapy in conjunction with POC testing minimizes patient's exposure to blood products and improves clinical outcome.
Anaortic, Total-Arterial, Off-Pump Coronary Artery Bypass Surgery-Why Bother
Some recent trials comparing conventional on-pump CABG with OPCAB have questioned the efficacy of the off-pump technique - these are most often performed with manipulation of the ascending aorta. We review the potential benefits of the anaortic, total-arterial OPCAB technique to explain why it is being employed by an increasing number of surgeons.
Lipids and Cardiovascular Disease: Do the Findings and Therapy Apply Equally to Men and Women
Dyslipoproteinemia is prevalent in women as well as in men. In both, its consequences--premature atherosclerosis and CAD morbidity and mortality--are more common. Although clinical evidence of the benefits of cholesterol lowering is less abundant in women, it is not entirely absent.
Right Atrial Myxoma and Severe Left Ventricular Dysfunction: Which Explanations? Which Management?
A 57 year-old woman with a large right atrial myxoma underwent emergency surgical resection in our institute. It is known that surgical management of such tumours is difficult regarding venous cannulation and embolic risk, but in our patient, the surgery was more challenging because of the severe left ventricular dysfunction.
Cyclosporine A Normalizes Mitochondrial Coupling, Reactive Oxygen Species Production, and Inflammation and Partially Restores Skeletal Muscle Maximal Oxidative Capacity in Experimental Aortic Cross-Clamping
Cyclosporine A normalized ROS production, decreased inflammation, and restored mitochondrial coupling during aortic cross-clamping. Incomplete V(max) protection might be due to low cyclophilin D expression in gastrocnemius, preventing CsA from blocking mPTP opening.
Diabetes Clinical Trials: Helped or Hindered by the Current Shift in Regulatory Requirements
The potential for some agents to increase the risk of cardiovascular events has led to substantial changes in regulatory requirements for new anti-diabetic therapies. These requirements, while key to ensuring the cardiovascular safety of new agents, fail to emphasize the need to show clinical benefits, such as less visual impairment, less need for dialysis, or fewer cardiovascular events and deaths.
Atrial Fibrillation, Blood Loss, and Transfusion in Patients with Left Ventricular Dysfunction: What is the Effect of Cardiopulmonary Bypass
This study examines outcomes in patients with left ventricular dysfunction after revascularization with and without CPB.