The Inflammatory Response to Cardiac Surgery with Cardiopulmonary Bypass: Should Steroid Prophylaxis be Routine
In adult cardiac surgery with CPB, steroids have been rigorously evaluated in multiple randomized clinical trials and meta-analyses.
Dexamethasone Levels Predict Cortisol Response after Infant Cardiopulmonary Bypass
We hypothesized that postoperative dexamethasone drug levels are highly variable, and that the infant stress response is related inversely to the amount of dexamethasone measured in the blood.
The “Benefits” of the Mini-Extracorporeal Circulation in the Minimal Invasive Cardiac Surgery Era
Mini-extracorporeal circulation (MECC) constitutes a novel miniaturized cardiopulmonary bypass (CPB) circuit, heparin-coated and primed with aprotinin.
Stem Cell Therapy for Chronic Ischaemic Heart Disease and Congestive Heart Failure
A promising approach to the treatment of chronic ischaemic heart disease (IHD) and heart failure is the use of stem cells.
Indications for Cardiopulmonary Bypass During Pregnancy and Impact on Fetal Outcomes
Cardiac operations in pregnant patients are a challenge for physicians in multidisciplinary teams due to the complexity of the condition which affects both mother and baby.
Blood Conservation Strategies in Cardiac Surgery: More is Better
Recent data show that up to 50% of heart procedures require blood transfusion, which can have adverse long- and short-term outcomes for the patient. This led to the updated 2011 Society of Thoracic Surgery (STS)/Society of Cardiovascular Anesthesiologists (SCA) guidelines in an attempt to adopt more effective blood conservation techniques.
Impaired Red Blood Cell Deformability after Transfusion of Stored Allogeneic Blood but not Autologous Salvaged Blood in Cardiac Surgery Patients
We tested the hypothesis that in cardiac surgery patients, RBC deformability and aggregation are minimally affected by CPB with autologous salvaged blood alone but are negatively affected by the addition of stored allogeneic blood.
Hyperkalemic Cardioplegia for Adult and Pediatric Surgery: End of an Era?
This review provides a brief history of high K(+) cardioplegia, five areas of increasing concern with prolonged membrane K(+) depolarization, and the basic science and clinical data underpinning a new normokalemic, "polarizing" cardioplegia comprising adenosine and lidocaine (AL) with magnesium (Mg(2+)) (ALM™).
Extracorporeal Life Support Devices and Strategies for Management of Acute Cardiorespiratory Failure in Adult Patients: A Comprehensive Review
This article summarises the available ECLS options
The Effects of Propofol Cardioplegia on Blood and Myocardial Biomarkers of Stress and Injury in Patients with Isolated Coronary Artery Bypass Grafting or Aortic Valve Replacement using Cardiopulmonary Bypass
The Propofol cardioplegia for Myocardial Protection Trial (ProMPT) aims to translate the successful animal intervention to the human clinical setting
Perioperative Considerations in a Sickle Cell Patient Undergoing Cardiopulmonary Bypass
An 11-year-old child, a known case of sickle cell anaemia with a history suggestive of sickling crisis in the past was scheduled for surgical pulmonary valvotomy.
Effects of the Breed, Sex and Age on Cellular Content and Growth Factor Release from Equine Pure-Platelet Rich Plasma and Pure-Platelet Rich Gel
The objectives of this study were: 1) to compare the cellular composition of P-PRP with whole blood and platelet poor plasma (PPP); 2) to compare the concentration of transforming GF beta 1 (TGF-β1) and platelet derived GF isoform BB (PDGF-BB) between P-PRP treated with non-ionic detergent (P-PRP+NID), P-PRG (activated with calcium gluconate -CG-), PPP+NID, PPP gel (PPG), and plasma and; 3) to evaluate and to correlate the effect of the breed, gender and age on the cellular and GF concentration for each blood component.