A Review of Postoperative Cognitive Dysfunction and Neuroinflammation Associated with Cardiac Surgery and Anaesthesia
We briefly discuss the evidence for cardiopulmonary bypass-related neuronal injuries in adult cardiac surgery patients, and review the evidence that immune priming is a key factor in the pathogenesis of cognitive dysfunction after cardiac surgery.
Percutaneous Mechanical Support for the Failing Right Heart
This article considers the available mechanical approaches to provide hemodynamic support to treat profound RV failure in the common clinical scenarios in which percutaneous mechanical RV support may be most beneficial.
Short-Acting P2Y12 Blockade to Reduce Platelet Dysfunction and Coagulopathy During Experimental Extracorporeal Circulation and Hypothermia
This experimental study tested P(2)Y(12) receptor blockade as an approach to protect platelets during ECC.
Non-Invasive Estimation of Jugular Venous Oxygen Saturation: A Comparison Between Near Infrared Spectroscopy and Transcutaneous Venous Oximetry
Placement of cerebral oximetry patches directly over the internal jugular vein (as opposed to on the forehead) appeared to approximate internal jugular venous saturation better...
Low-Flow Antegrade Cerebral Perfusion Attenuates Early Renal and Intestinal Injury During Neonatal Aortic Arch Reconstruction
These results substantiate earlier suggestions that ACP provides more abdominal organ protection than DHCA in neonates undergoing aortic arch reconstruction.
Cold Reperfusion Before Rewarming Reduces Neurological Events after Deep Hypothermic Circulatory Arrest
Before rewarming, a 10-min period of cold perfusion significantly reduces incidence of NE.
A Modified Protocol for Retrograde Cerebral Perfusion: Magnetic Resonance Spectroscopy in Pigs
Application of the modified RCP protocol significantly improved cerebral energy conservation during HCA and accelerated energy recovery after rewarming.
Is it Worth Packing the Head with Ice in Patients Undergoing Deep Hypothermic Circulatory Arrest?
We conclude that topical head cooling with ice is of use during DHCA but not during rewarming following DHCA and that it may be possible to advance topical head cooling techniques using circulating water rather than packed ice.
Are Right Ventricular Risk Scores Useful?
The use of risk scores failed to predict the need of RV support after LVAD.
Right Ventricular Dysfunction Following Continuous Flow Left Ventricular Assist Device Placement in 51 Patients: Predicators and Outcomes
The adjustment of septal deviation through gradual increase of the LVAD flow can prevent the acute RV dysfunction following LVAD placement.
Alloimmunosensitization in Left Ventricular Assist Device Recipients and Impact on Posttransplantation Outcome
Despite the clinical success of these devices, it has been reported that many patients bridged to transplantation with mechanical support develop circulating antibodies with potential donor reactivity.
Cerebral Protection during Controlled Hypoperfusion in a Piglet Model: Comparison of Moderate (25°C) versus Deep (18°C) Hypothermia at Various Flow Rates Using Intraoperative Measurements and Ex Vivo Investigation
The aim of this study was to evaluate the effectiveness and safety of controlled cerebral hypoperfusion at moderate (25°C) versus deep (18°C) hypothermia.