Cell-Derived Microparticles in Stored Blood Products: Innocent-Bystanders or Effective Mediators of Post-Transfusion Reactions?
Plasma membrane-derived microvesicles or microparticles (MPs) are sub-cellular vesicles released upon shear stress, cell activation, injury or apoptosis.
The Influence of Heparin Resistance on Postoperative Complications in Patients Undergoing Coronary Surgery
Severe form of heparin resistance (expressed by the ACT less than 480 seconds after 400 U/kg heparin) was an independent predictor of death.
Increased Long-Term Mortality with Plasma Transfusion after Coronary Artery Bypass Surgery
This study explores the relation between the transfusion of different blood components and long-term mortality.
Fresh and Stored Red Blood Cell Transfusion Equivalently Induce Subclinical Pulmonary Gas Exchange Deficit in Normal Humans
We tested the hypothesis that transfusion can cause mild pulmonary dysfunction that has not been noticed clinically and is not sufficiently severe to fit the definition of transfusion-related acute lung injury.
Impact of Transfusion of Autologous 7- versus 42-Day-Old AS-3 Red Blood Cells on Tissue Oxygenation and the Microcirculation in Healthy Volunteers
Transfusion of 1 unit of 42-day-stored RBCs to healthy subjects has no overt detrimental effect on tissue oxygenation or the microcirculation assessed by clinically available monitors.
Peroperative Effects of Fresh Frozen Plasma and Antithrombin III on Heparin Sensitivity and Coagulation during Nitroglycerine Infusion in Coronary Artery Bypass Surgery
ATIII may be preferred to FFP in patients with heparin resistance due to NTG infusion undergoing CABGS.
Microparticles from Stored Red Blood Cells Activate Neutrophils and Cause Lung Injury after Hemorrhage and Resuscitation
The presence of MPs in stored units can be associated with adverse effects, including lung injury, after transfusion.
A Pilot Feasibility Trial of Allocation of Freshest Available Red Blood Cells versus Standard Care in Critically Ill Patients
We aimed to evaluate in intensive care unit (ICU) patients 1) the feasibility of allocating freshest available compatible RBCs versus standard care and 2) the suitability of this approach in the design of a large randomized controlled trial (RCT).
Use of Prothrombin Complex Concentrate for Excessive Bleeding after Cardiac Surgery
Administration of low-dose of PCC significantly decreased postoperative bleeding after CPB.
Longer Blood Storage is Associated with Suboptimal Outcomes in High-Risk Pediatric Cardiac Surgery
The freshest RBC units available should be used for pediatric cardiac operations expected to require more than 4 units or more than 150 mL/kg of allogeneic RBC transfusions, with no units more than 14 days old being transfused whenever possible.
Effect of Processing and Storage on Red Blood Cell Function In Vivo
Red blood cell (RBC) transfusion is indicated to improve oxygen delivery to tissue, and for no other purpose.
Fibrinogen Concentrate Therapy in Complex Cardiac Surgery
This study reports the initial clinical use of fibrinogen concentrate in complex cardiac surgery.