The Effect of Vasopressin on the Hemodynamics in CABG Patients

BACKGROUND:

Vasopressin is widely used to
treat various type of hypotension, but the effect of vasopressin on
coronary artery bypass grafting surgery (CABG) patients is not clear.
This study was to investigate the effect of vasopressin on the
hemodynamics in CABG patients.

METHODS:

Twenty coronary
artery disease (CAD) patients were randomly divided into two groups:
norepinephrine group and vasopressin group. During the anesthesia and
the operation, the central venous pressure (CVP) and pulmonary capillary
wedge pressure (PCWP) were maintained to 8-10cmH2O, and the hemocrit
was maintained above 30% through lactate ringer’s mixture, artifact
colloid and red blood cells. The invasive artery blood pressure (IBP)
was maintained by appropriate anesthetic depth and norepinephrine or
vasopressin respectively. The target IBP was 70 mmHg, and heart rate
(HR) was 60 bpm. The MAP (mean artery pressure), HR, ST-T, CVP, PAP
(pulmonary artery pressure), PCWP, SVR (systemic vascular resistance),
PVR (pulmonary vascular resistance), CO (cardiac output), urine output,
blood gas analysis, surgery duration and blood loss were monitored.

RESULTS:

The
MAP, HR, and ST-T were stable in either group during the operation.
CVP, PCWP and SVR increased but CI deceased during the posterior
descending artery (PDA) was grafted in both groups and without any
significant difference between them. PAP increased during PDA was
grafted in either group and there was significant difference between the
two groups. PVR increased during ADA and PDA being grafted in
norepinephrine group but not in vasopressin group. Metoprolol usage was
11.2 mg and 5.9 mg in norepinephrine group and vasopressin group
respectively.

CONCLUSION:

Vasopressin was better than norepinephrine.to keep the hemodynamics stability of patients undergoing CABG surgery.