Using Platelet-Rich Plasma (PRP) to Improve Bone Regeneration in Implant Bone Defect

OBJECTIVE: To evaluate the result of bone regeneration due to using PRP in combination with beta-TCP in bone defect adjacent to oral implantation.

METHODS: Ten patients (6 males, 4 females, with an average age of 49.6 years) participated in this study. Seven of them underwent maxillary sinus augmentations, and 3 underwent GBR for peri-implant bone defects. PRP + beta-TCP was used in 4 cases and beta-TCP in other 6 as control. X-ray examinations were carried out prior to operation and in 1 week, at 3 months, 6 months after operation. After 4 – 6 months, 3 biopsy specimens were obtained at the time of the second stage operation in each group.

RESULTS: Bone grafts healed well without any infection in all cases. Radiographs showed that bone grafts integrated together with the bone. The histological result showed that new bone was formed among particles of beta-TCP in both groups, but in PRP + beta-TCP group denser and better arranged woven bone was observed, and more new bone was formed into the micropores of the particles.

CONCLUSIONS: The Results esult in this study implied that PRP in combination with beta-TCP can improve bone regeneration in bone defect adjacent to oral implantation.