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A Novel Antidote-Controlled Anticoagulant Reduces Thrombin Generation and Inflammation and Improves Cardiac Function in Cardiopulmonary Bypass Surgery
Here we demonstrate that an anticoagulant aptamer-antidote pair targeting factor IXa can replace heparin and protamine in a porcine CPB model and also limit the adverse effects on thrombin generation, inflammation, and cardiac physiology associated with heparin and protamine use.
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Nadir Oxygen Delivery During Pediatric Bypass as A Predictor of Acute Kidney Injury
The lowest suitable DO 2i during CPB in the present population undergoing pediatric cardiac surgery was 353 mL/min/m 2. And below this threshold, there was a high probability of inducing CS-AKI.
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Overview of the 2012 Food and Drug Administration Circulatory System Devices Panel Meeting on the Reclassification of External Counterpulsation, Intra-Aortic Balloon Pump, and Non-Roller-Type Cardiopulmonary Bypass Blood Pump Devices
The Food and Drug Administration held a Circulatory System Devices Advisory Panel meeting,
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