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Effect of Erythropoietin on the Incidence of Acute Kidney Injury Following Complex Valvular Heart Surgery: A Double Blind, Randomized Clinical Trial of Efficacy and Safety
Intravenous administration of 300 IU/kg of EPO did not provide renal protection in patients who are at increased risk of developing AKI after undergoing complex valvular heart surgery.
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Acute Kidney Injury Post-Heart Transplant: An Analysis of Peri-Operative Risk Factors
Risk factors found to be associated with the presence of acute kidney injury included increased use of vasopressors and inotropes post‐transplant. Protective factors included cardiopulmonary bypass time <170 min. Acute kidney injury was found to be associated with increased 30‐day and 1‐year mortality.
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Altered Fibrinolysis during and after Surgery
Major surgery induces hemostatic changes related to surgical stress, tissue destruction, and inflammatory reactions. These changes involve a shift of volume from extravascular space to intravascular and interstitial spaces, a “physiologic” hemodilution of coagulation proteins, and an increase of plasmatic fibrinogen concentration and platelets.
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