Platelet Function Testing in Patients on Antiplatelet Therapy before Cardiac Surgery

Bleeding and transfusion, common challenges in cardiac surgery, are influenced by comorbidity, the complexity of surgery, hypothermia, and the specifics of cardiopulmonary bypass inducing hemodilution, thrombin generation, fibrinolysis, and platelet dysfunction. Nearly 11% of patients with acute coronary syndromes undergo coronary artery surgery during dual antiplatelet therapy.  Although preoperative P2Y₁₂ receptor inhibitor therapy may reduce ischemic events, late preoperative exposure to P2Y₁₂ receptor inhibitors increases the risk of surgery-associated bleeding and reoperation for bleeding.