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Perfusion NewswireMain ZonePlatelet-Dependent Thrombography Gives a Distinct Pattern of In Vitro Thrombin Generation after Surgery with Cardio-Pulmonary Bypass: Potential Implications

Platelet-Dependent Thrombography Gives a Distinct Pattern of In Vitro Thrombin Generation after Surgery with Cardio-Pulmonary Bypass: Potential Implications

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BACKGROUND: Bleeding remains a potentially lethal complication of cardio-pulmonary bypass (CPB) surgery. The purpose of this study was to obtain a better insight into in vitro thrombin generation in the context of CPB.


METHODS:


We used Calibrated Automated Thrombography to assess blood coagulation of 10 low-risk patients operated for valve replacement with CPB, under 2 experimental conditions, one implicating platelets as platelet dysfunction has been described to occur during CPB.


RESULTS:


Our main finding was that CPB-induced coagulopathy was differently appreciated depending on the presence or absence of platelets: the decrease in thrombin generation was much less pronounced in their presence (mean endogenous thrombin potential change values before and after CPB were -3.9% in the presence of platelets and -39.6% in their absence).


CONCLUSION:


Our results show that experimental conditions have a profound effect in the study of in vitro thrombin generation in the context of CPB.

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