High-Dose Polymerized Hemoglobin Fails to Alleviate Cardiac Ischemia/Reperfusion Injury Due to Induction of Oxidative Damage in Coronary Artery
This study was designed to investigate whether glutaraldehyde-polymerized human placenta hemoglobin (PolyPHb), a hemoglobin-based oxygen carrier (HBOC), can protect heart against cardiopulmonary bypass (CPB)-induced ischemia/reperfusion (I/R) injury or not and to elucidate the underlying mechanism.