Comparison of Hollow-Fiber Membrane Oxygenators in Terms of Pressure Drop of the Membranes During Normothermic and Hypothermic Cardiopulmonary Bypass in Neonates

In light of the existing concerns on HES use, this study leaves several unanswered questions: how should patients be informed when they are asked to participate in a clinical trial that may randomise them to receive HES? How can a prestigious research group consider it appropriate to adopt a ’non‐inferiority’ study design to evaluate the safety profile of a controversial drug such as HES, when any proven beneficial effects (if there are any) remain unanswered?