COVID-19 Associated Hypercoagulability Manifestations, Mechanisms, and Management
In this narrative review, we summarize clinical manifestations of COVID-19, mechanisms, monitoring considerations, and anticoagulant therapy. We also review unique considerations for COVID-19 patients who are on extracorporeal membrane oxygenation.
Hypoxic Storage of Red Blood Cells Improves Metabolism and Post-Transfusion Recovery
Hypoxic storage improves energy and redox metabolism of stored RBCs, which results in improved posttransfusion recoveries in healthy autologous recipients—a Food and Drug Administration gold standard of stored blood quality. In addition, we identified candidate metabolic predictors of PTR for RBCs stored under standard and hypoxic conditions.
Factors Associated with Errors in The Heparin Dose Response Test: Recommendations to Improve Individualized Heparin Management in Cardiopulmonary Bypass
The mACT can be substantially different from eACT. The accuracy of the HDR test appears to be dependent upon bACT, slope, and CHC. Based on our analysis, we provide several recommendations and a flow chart to improve the quality of individualized heparin management on CPB.
Platelet Function Testing in Patients on Antiplatelet Therapy before Cardiac Surgery
Although preoperative P2Y12 receptor inhibitor therapy may reduce ischemic events, late preoperative exposure to P2Y12 receptor inhibitors increases the risk of surgery-associated bleeding and reoperation for bleeding.
Impact Of 6% Balanced Hydroxyethyl Starch Following Cardiopulmonary Bypass on Renal Function: A Retrospective Study
The moderate dose administration of HES (≥20 ml/kg) in the postoperative period following cardiac surgery might be associated with the risk of AKI. However, it was not associated with serious adverse outcomes such as new RRT or mortality. Further randomized controlled studies are needed to validate study results.
Anti-Xa Versus Time-Guided Anticoagulation Strategies in Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis
In this meta-analysis of observational studies of patients on ECMO, an anti-Xa-based anticoagulation strategy, when compared to a time-based strategy, was associated with fewer bleeding events and mortality rate, without an increase in thrombotic events.
Limited Effect of Red Blood Cell Transfusion on Long-Term Mortality Among Anaemic Cardiac Surgery Patients
No statistically significant association between RBC transfusion and long-term mortality was found when we adjusted for known risk factors. This study suggests that the observed difference in mortality in this patient group is largely due to patient-related risk factors.
Bacteremia in The Red Blood Cells Obtained from The Cell Saver in Patients Submitted to Heart Surgery
The microbiological characteristics of the red blood cells obtained after processing autologic blood recovered with the cell saver during heart surgery are of GRAM+ bacterial origin, the most isolated species being Staphylococcus epidermidis.
External Validation of The Pediatric Extracorporeal Membrane Oxygenation Prediction Model for Risk Adjusting Mortality
While the model overestimates mortality for the highest risk patients, it remains the only prediction model applicable to both neonates and pediatric patients who require ECLS for any indication and thus maintains potential for application in research and quality benchmarking.
Perioperative Complications in A Paediatric Cardiac Surgery Program with Limited Systemic Resources
Despite the comparable crude mortality, the operative mortality among patients with perioperative complications in our series was significantly higher than in the developed world. A number of initiatives are needed in order to improve failure-to-rescue rates in low- and middle-income countries.
Investigation of the Relationship between Cerebral Near-Infrared Spectroscopy Measurements and Cerebrovascular Event in Coronary Artery Bypass Grafting Operation in Patients without Carotid Stenosis and Patients with Carotid Stenosis below Surgical Margins
The follow-up of cerebral perfusion with a method like near-infrared spectroscopy (NIRS) will ensure that MAP is adjusted with interventions that will be made according to changes in NIRS. Thus, it will be possible to avoid unnecessary medication and flow-rate increase with cerebral oxygen saturation (rSO2) follow-up.
Longest Incubation Period of Mycobacterium Chimaera Infection After Cardiac Surgery.
The present experience indicates that all patients who underwent open heart procedures since 2006 with such heater–cooler unit model should be closely followed up regardless of time of index surgery.