Fresh and Stored Red Blood Cell Transfusion Equivalently Induce Subclinical Pulmonary Gas Exchange Deficit in Normal Humans
We tested the hypothesis that transfusion can cause mild pulmonary dysfunction that has not been noticed clinically and is not sufficiently severe to fit the definition of transfusion-related acute lung injury.
Advances in Mechanical Circulatory Support in the Treatment of Heart Failure
In recent years, the implantation of Ventricular Assist Devices (VAD) as definitive therapy (DT) has emerged as a promising replacement therapy for heart transplantation.
The Pharmacotherapy Implications of Ventricular Assist Device in the Patient with End-Stage Heart Failure
A basic understanding of this unique therapy can assist pharmacists in attending to the needs of patients with VAD.
Anticoagulation and Bleeding in Patients with Ventricular Assist Devices: Walking the Tightrope
A left ventricular assist device (LVAD) is a lifesaving therapy for end-stage heart failure, but it is associated with major complications such as bleeding and thrombosis.
Practical Considerations of Percutaneous Ventricular Assist Devices
Percutaneous ventricular assist devices are increasingly used today, allowing the scope of left ventricular support to move out of the operating room and into the interventional suite and cardiovascular care unit.
Pulsatile Control of Rotary Blood Pumps: Does the Modulation Waveform Matter?
A synchronized pulsing rotary blood pump offers a simple and powerful control modality for heart unloading.
Performance Evaluation of a Pediatric Viscous Impeller Pump for Fontan Cavopulmonary Assist
A VIP will augment Fontan cavopulmonary flow in the proper pressure and flow ranges, with low hemolysis risk under more stringent pediatric scale and physiology compared with adult scale.
Cost-Effectiveness of the Implantable HeartMate II Left Ventricular Assist Device for Patients Awaiting Heart Transplantation
Although HeartMate II LVAD implantation significantly increases survival compared with conventional medical management, it does not provide good value for the money spent according to established thresholds of cost-effectiveness in the UK.
Low Incidence of Bleeding-Related Morbidity with Left Ventricular Assist Device Implantation in the Current Era
The potential to reduce bleeding reduces invasiveness of LVAD surgery, reduces allosensitization, may improve outcomes, and may increase mainstream acceptability of LVADs as definitive therapy for heart failure.
Discontinuation of HeartWare RVAD Support without Device Removal in Chronic BIVAD Patients
The HeartWare HVAD used as an RVAD may be stopped and left in place without complications.
The Early Inflammatory Response in A Mini-Cardiopulmonary Bypass System: A Prospective Randomized Study
The Medtronic RHS may induce less systemic inflammation than conventional CPB systems, particularly when cardiotomy suction was used, but it did not result in improved clinical benefit.
Alloimmunosensitization in Left Ventricular Assist Device Recipients and Impact on Posttransplantation Outcome
Despite the clinical success of these devices, it has been reported that many patients bridged to transplantation with mechanical support develop circulating antibodies with potential donor reactivity.