Outcomes of Individualized Goal-Directed Therapy Based on Cerebral Oxygen Balance in High-Risk Patients Undergoing Cardiac Surgery: A Randomized Controlled Trial
In high-risk patients undergoing cardiac surgery, individualized GDT therapy did not yield better outcomes, however, the achievement of preoperative individual targets may be associated with less morbidity.
The Impact of Minimal Invasive Extracorporeal Circulation on Postoperative Kidney Function
Our findings challenge the superiority of minimal invasive compared to conventional extracorporeal circulation in terms of preservation of renal function following low-risk coronary surgery.
Factors Associated with Errors in The Heparin Dose Response Test: Recommendations to Improve Individualized Heparin Management in Cardiopulmonary Bypass
Based on our analysis, we provide several recommendations and a flow chart to improve the quality of individualized heparin management on CPB.
Interaction of Heparin and Protamine in Presence of Overdosage: In Vitro Study
We reconfirmed that the ROTEM device enables discrimination of the effects heparin and protamine on coagulation and detection of the coagulation-impairing effects of protamine overdosage. Furthermore, we were able to show a positive effect on coagulation times by heparin in the presence of protamine overdosage.
A Comparative Analysis of Four Activated Clotting Time Measurement Devices in Cardiac Surgery with Cardiopulmonary Bypass
Careful validation must be undertaken when adopting a different method as decision limits would be affected. Clinicians should also be cautious using ACT as the only indicator for full heparin reversal.
COVID-19 Associated Hypercoagulability Manifestations, Mechanisms, and Management
In this narrative review, we summarize clinical manifestations of COVID-19, mechanisms, monitoring considerations, and anticoagulant therapy. We also review unique considerations for COVID-19 patients who are on extracorporeal membrane oxygenation.
Factors Associated with Errors in The Heparin Dose Response Test: Recommendations to Improve Individualized Heparin Management in Cardiopulmonary Bypass
The mACT can be substantially different from eACT. The accuracy of the HDR test appears to be dependent upon bACT, slope, and CHC. Based on our analysis, we provide several recommendations and a flow chart to improve the quality of individualized heparin management on CPB.
Platelet Function Testing in Patients on Antiplatelet Therapy before Cardiac Surgery
Although preoperative P2Y12 receptor inhibitor therapy may reduce ischemic events, late preoperative exposure to P2Y12 receptor inhibitors increases the risk of surgery-associated bleeding and reoperation for bleeding.
Bacteremia in The Red Blood Cells Obtained from The Cell Saver in Patients Submitted to Heart Surgery
The microbiological characteristics of the red blood cells obtained after processing autologic blood recovered with the cell saver during heart surgery are of GRAM+ bacterial origin, the most isolated species being Staphylococcus epidermidis.
Investigation of the Relationship between Cerebral Near-Infrared Spectroscopy Measurements and Cerebrovascular Event in Coronary Artery Bypass Grafting Operation in Patients without Carotid Stenosis and Patients with Carotid Stenosis below Surgical Margins
The follow-up of cerebral perfusion with a method like near-infrared spectroscopy (NIRS) will ensure that MAP is adjusted with interventions that will be made according to changes in NIRS. Thus, it will be possible to avoid unnecessary medication and flow-rate increase with cerebral oxygen saturation (rSO2) follow-up.
Longest Incubation Period of Mycobacterium Chimaera Infection After Cardiac Surgery.
The present experience indicates that all patients who underwent open heart procedures since 2006 with such heater–cooler unit model should be closely followed up regardless of time of index surgery.
Comparative Changes of Pre-Operative Autologous Transfusions and Peri-Operative Cell Salvage in The United States
There was a significant decrease in PAD red blood cell transfusions, while PACS has increased and subsequently decreased; PACS plays an important role in surgical blood conservation.