Thrombus Growth and Embolism on Tissue Factor-Bearing Collagen Surfaces under Flow: Role of Thrombin with and without Fibrin
At sites of vascular injury, thrombin is an important mediator in thrombus growth and stability.
Should Women Receive Left Ventricular Assist Device Support?: Findings from INTERMACS
Small studies have reported women to have worse outcomes and more adverse events after implantation of mechanical circulatory support device compared with men.
Prognostic Importance of Preoperative Anti-PF4/Heparin Antibodies in Patients Undergoing Cardiac Surgery. A Systematic Review
There does appear to be an association between anti-PF4/heparin antibodies and non-thromboembolic adverse events, but a causal relationship is unlikely.
Incidence and Management of Gastrointestinal Bleeding with Continuous Flow Assist Devices
Continuous flow left ventricular assist devices (CF-LVADs) have emerged as the standard of care for patients in advanced heart failure (HF) requiring long-term mechanical circulatory support. Gastrointestinal (GI) bleeding has been frequently reported within this population.
The Effects of Conventional Extracorporeal Circulation Versus Miniaturized Extracorporeal Circulation on Microcirculation During Cardiopulmonary Bypass-Assisted Coronary Artery Bypass Graft Surgery
To reduce the complications associated with cardiopulmonary bypass (CPB) during cardiac surgery, many modifications have been made to conventional extracorporeal circulation systems.
Pharmacokinetic Changes in Patients Receiving Extracorporeal Membrane Oxygenation
Extracorporeal membrane oxygenation further complicates the management of critically ill patients who already have profound physiologic derangements with consequent altered pharmacokinetics.
Eye-Tracking Analysis of Skilled Performance in Clinical Extracorporeal Circulation
Eye-tracking data on four perfusionists were recorded while they were manipulating the ECC during a series of cardiovascular surgeries.
Bivalirudin and Post-Cardiotomy ECMO: A Word of Caution
Bivalirudin has been proposed as the sole anticoagulant in patients under extracorporeal membrane oxygenation (ECMO) or cardiopulmonary bypass.
Long-term Mechanical Circulatory Support (Destination Therapy): On Track to Compete with Heart Transplantation?
Average 2-year survival after cardiac transplantation is approximately 80%.
Changes in Mechanical Fragility and Free Hemoglobin Levels after Processing Salvaged Cardiopulmonary Bypass Circuit Blood with a Modified Ultrafiltration Device
This study evaluated the extent of hemolysis, the mechanical fragility index (MFI), and the amount of plasma free hemoglobin (PFHb) created after processing with the MUF device.
Change in Heparin Potency and Effects on the Activated Clotting Time in Children Undergoing Cardiopulmonary Bypass
In this investigation we provide objective evidence that the level of anticoagulation after the initial pre-CPB heparin bolus as assessed by the ACT is significantly less with use of the new heparin.
Washing of Banked Blood by Three Different Blood Salvage Devices
Washing improves the quality of stored RBCs, and autotransfusion devices have been proposed for intraoperative processing, but these devices were designed for diluted wound blood, and limited data on their performance with RBCs are available.