Platelet Concentrates, from Whole Blood or Collected by Apheresis
The quality and characteristics of platelets during storage are affected by a number of factors, such as anticoagulant, centrifugation and processing after collection, and pre- or post storage pooling, but when comparing literature on the various methods, most differences balance out.
Low Hemorrhage-Related Mortality in Trauma Patients in a Level I Trauma Center Employing Transfusion Packages and Early Thromboelastography-Directed Hemostatic Resuscitation with Plasma and Platelets
This was a prospective study of adult trauma patients admitted to a Level I trauma center. Demography, Injury Severity Score (ISS), transfusion therapy, and mortality were registered. Hemostatic resuscitation was based on a massive transfusion protocolencompassing transfusion packages and thromboelastography (TEG)-guided therapy.
Massive Bleeding and Massive Transfusion
This review surveys current literature on fluid resuscitation, blood transfusion, and hemostatic agents currently used during massive hemorrhage in order to optimize patients'blood and coagulation management in emergency medical aid.
Evolution of US Military Transfusion Support for Resuscitation of Trauma and Hemorrhagic Shock
Here we review the lessons learned by coalition medical personnel regarding resuscitation of severe trauma, integrating knowledge gained from massive transfusion, autopsies, and extensive review of medical records contained in the Joint Theater Trauma Registry. Changes in clinical care included the shift to resuscitation with 1:1:1 component therapy, use of fresh whole blood, and the application of both medical devices and pharmaceutical adjuncts to reduce bleeding.
Tranexamic Acid in Remote Damage Control Resuscitation
In this paper, the authors review the current state of the art for tranexamic acid (TXA) and its potential benefits to those patients who are in need of a massive transfusion. Specifically addressed are its biologic and pharmacologic properties, as well the results of a number of recent studies.
An Observational Study of the Fresh Frozen Plasma: Red Blood Cell Ratio in Postpartum Hemorrhage
In this retrospective study, a higher FFP:RBC ratio was associated with a lower requirement for advanced interventional procedures in the setting of postpartum hemorrhage.
Hypercoagulation Assessed by Thromboelastography is Neither Related to Infarct Size nor to Clinical Outcome After Primary Percutaneous Coronary Intervention
We investigated the relationship between coagulation assessed by thromboelastography (TEG) and myocardial damage in ST-segment elevation myocardial infarction (STEMI).
Impact of Retransfusion of Blood Processed in Cell-Saver on Coagulation Versus Cardiopulmonary Bypass: A Prospective Observational Study Using Thromboelastography
In this study we compared an impact of retransfusion of blood processed in cell-saver (CS) with that of cardiopulmonary bypass (CPB) on blood coagulation in patients undergoing cardiac surgery.
TEG® and ROTEM® in Trauma: Similar Test but Different Results
This review evaluates the comparability between TEG and ROTEM and performs a descriptive review of the parameters utilized in each test in adult trauma patients.
Potential Value of Transfusion Protocols in Cardiac Surgery
This article reviews the current literature between 1995 and 2012 dealing with transfusion protocols in cardiovascular surgery. The 16 studies fitting these search criteria have evaluated the impact of the implementation of ROTEM/TEG based coagulation management algorithms on transfusion requirement and outcome in overall 8507 cardiovascular surgical patients.
Monitoring Incomplete Heparin Reversal and Heparin Rebound After Cardiac Surgery
In this study we assessed the incidence of incomplete heparin reversal and heparin rebound after cardiac surgery with cardiopulmonary bypass (CPB) and the ability of the activated coagulation time (ACT) and thromboelastography (TEG) to detect these phenomena. DESIGN:
Preoperative Statin Therapy in Cardiac Surgery is More Effective in Patients Who Display Preoperative Activation of the Inflammatory System
We sought to determine whether preoperative statin treatment is more effective in reducing, after cardiac surgery with cardiopulmonary bypass, systemic inflammatory response and myocardial damage markers in patients who have elevated preoperative interleukin-6 levels than in patients who have normal preoperative interleukin-6 levels. The study involved a prospective cohort of 164 patients who underwent coronary and valvular surgery with cardiopulmonary bypass.