Computational Fluid Dynamic Analysis to Prevent Aortic Root and Valve Clots during Left Ventricular Assist Device Support
Aortic root and valve clots are rare but well described in patients on maximal left ventricular assist device (LVAD) support.
Pilot Alternating Treatment Design Study of the Splanchnic Metabolic Effects of Two Mean Arterial Pressure Targets during Cardiopulmonary Bypass
The arterial pressure target for optimal splanchnic function during cardiopulmonary bypass (CPB) is uncertain.
Direct Innominate Artery Cannulation for Antegrade Cerebral Perfusion in Neonates undergoing Arch Reconstruction
The purpose of the present study was to evaluate the flow measurements and safety of DC when compared with IC.
Comparison between d901 Lilliput 1 and Kids d100 Neonatal Oxygenators: Toward Bypass Circuit Miniaturization
In this study, we describe our clinical experience comparing performance of two neonatal oxygenators.
An Automated Method for Analysis of Microcirculation Videos for Accurate Assessment of Tissue Perfusion
The experimental algorithm automatically extracts microvascular network and quantitatively measures changes in the microcirculation
Excessive Negative Venous Line Pressures and Increased Arterial Air Bubble Counts during Miniaturized Cardiopulmonary Bypass: An Experimental Study Comparing Miniaturized with Conventional Perfusion Systems
Despite the benefits of MCPB regarding systemic inflammatory response and haemolysis, this technique is associated with excessive negative venous line pressures
Influence of Different Tranexamic Acid Administration Methods during and after Cardiac Surgery on Coagulation Function and Postoperative Blood Loss
This study evaluates the influence of different tranexamic acid administration methods during and after cardiac surgery with cardiopulmonary bypass(CPB) on coagulation function and postoperative bleeding.
Antifibrinolytics in Cardiac Surgery
Cardiac surgery exerts a significant strain on the blood bank services and is a model example in which a multi-modal blood-conservation strategy is recommended.
Assessment and Management of Massive Bleeding: Coagulation Assessment, Pharmacologic Strategies, and Transfusion Management
This review details the current knowledge in massive hemorrhage with regard to the pathophysiology and laboratory assessment of the coagulation disturbance, the role of plasma and platelet transfusion, the role of pharmaceutical strategies, and the clinical value of having a massive transfusion protocol.
Management of Massive Bleeding in 2013: Seven Questions and Answers
The management of massive bleeding has improved, thanks to high-quality blood components and new transfusion strategies. However, it remains controversial and, despite a huge body of literature, randomised control trials are still lacking.
Immediate Effects of Individualized Heparin and Protamine Management on Hemostatic Activation and Platelet Function in Adult Patients Undergoing Cardiac Surgery with Tranexamic Acid Antifibrinolytic Therapy
This randomized prospective study was initiated to clarify whether individualized heparin and protamine dosing has immediate effects on hemostatic activation and platelet function in adult cardiac surgery.
Antifibrinolytic Agents in Current Anaesthetic Practice
Antifibrinolytic drugs have become almost ubiquitous in their use during major surgery when bleeding is expected or commonplace. Inhibition of the fibrinolytic pathway after tissue injury has been consistently shown to reduce postoperative or traumatic bleeding. We have reviewed the current literature for this increasingly popular class of drugs to support clinical judgement in daily anaesthetic practice.