Improved Environmental Impact with Diversion of Perfusion Bypass Circuit to Municipal Solid Waste
The project goal was to reduce waste disposal volume, costs and minimize the negative impact that regulated waste treatment and disposal has on the environment.
From Bloodless Surgery to Patient Blood Management
Patient blood management strategies can be applied at every stage of care to surgical and nonsurgical patients, and they generally fall under one of these three categories (the so-called pillars of blood management): optimizing hematopoiesis and appropriate management of anemia, minimizing bleeding and blood loss, and harnessing and optimizing physiological tolerance of anemia through employing all available modalities while treatment is initiated.
Rationale and Design of the Investigation of the Management of Pericarditis (IMPI) Trial: a 2 × 2 Factorial Randomized Double-Blind Multicenter Trial of Adjunctive Prednisolone and Mycobacterium with Immunotherapy in Tuberculous Pericarditis
The primary objective of the IMPI Trial is to assess the effectiveness and safety of prednisolone and M. w immunotherapy in reducing the composite outcome of death, constriction, or cardiac tamponade requiring pericardial drainage in 1,400 patients with TB pericardial effusion.
Effect of an Investigational Vaccine for Preventing Staphylococcus Aureus Infections after Cardiothoracic Surgery: A Randomized Trial
This study evaluates the efficacy and safety of preoperative vaccination in preventing serious postoperative S. aureus infection in patients undergoing cardiothoracic surgery.
Preoperative Statin Therapy in Cardiac Surgery is More Effective in Patients Who Display Preoperative Activation of the Inflammatory System
We sought to determine whether preoperative statin treatment is more effective in reducing, after cardiac surgery with cardiopulmonary bypass, systemic inflammatory response and myocardial damage markers in patients who have elevated preoperative interleukin-6 levels than in patients who have normal preoperative interleukin-6 levels.
Orthotopic Replacement of Aortic Heart Valves with Tissue-Engineered Grafts
This study presents the function and morphological changes of a tissue-engineered aortic valve (TEV) compared to the cryopreserved valve (CPV), aortic valve (AV) allografts in an orthotopic position in sheep.
Fabrication of Small-Diameter Vascular Scaffolds by Heparin-Bonded P(LLA-CL) Composite Nanofibers to Improve Graft Patency
The poor patency rate following small-diameter vascular grafting remains a major hurdle for the widespread clinical application of artificial bloodvessels to date.
Blood Substitutes: Evolution from Non Carrying to Oxygen-and Gas-Carrying Fluids
The development of oxygen (O2)-carrying blood substitutes has evolved from the goal of replicating blood O2 transport properties to that of preserving microvascular and organ function, reducing the inherent or potential toxicity of the material used to carry O2, and treating pathologies initiated by anemia and hypoxia.
Cardiovascular Tissue Engineering Research Support at the National Heart, Lung, and Blood Institute
This article is a review of the tissue engineering programs of the National Heart, Lung, and Blood Institute, which support research efforts to translate novel approaches for the treatment of cardiovascular disease.
Should Jehovah’s Witness Patients be Listed for Heart Transplantation
This best evidence topic in Cardiac Surgery was written according to a structured protocol. The question addressed was: for [Jehovah's Witness patients with end-stage heart failure] can these patients undergo a [heart transplantation] without an increased rate of mortality.
A Retrospective Comparison of Blood Transfusion Requirements During Cardiopulmonary Bypass with Two Different Small Adult Oxygenators
A low haematocrit during cardiopulmonary bypass (CPB) is associated with adverse outcomes and often results in homologous blood transfusions.
Patient Blood Management – The New Frontier
As one of the oldest and most common procedures in clinical practice, allogeneic blood transfusions face many issues including questionable safety and efficacy, increasing costs and limited supply.