ZymoGenetics Submits Citizen Petition to FDA Requesting Removal of Bovine Thrombin from Market in the Interest of Patient Safety
ZymoGenetics, Inc. (NASDAQ:ZGEN), announced today the submission of a Citizen Petition to the U.S. Food and Drug Administration (FDA) requesting that the FDA remove Thrombin-JMI® Thrombin, topical (bovine origin) from the market in the interest of patient safety. The Citizen Petition is prompted by recent reports of serious or fatal bleeding-related adverse events in surgical patients exposed to bovine (cattle-derived) thrombin.
The Benefit of the Arterial Filter Exceeds the Risk in Small Children (Video)
Dave Fitzgerald discusses the use of arterial line filter in pediatric perfusion circuits (39 minutes).
Relationships Among Haemoglobin Level, Packed Red Cell Transfusion and Clinical Outcomes in Patients Affter Cardiac Surgery
To vetify associations among haemoglobin (Hb) concentrations, blood transfusions, and clinical outcomes in patients after cardiac surgery, especially in those who undergo valve replacement or bypass surgery.
Timing and Incidence of Postoperative Infections Associated With Blood Transfusion: Analysis of 1,489 Orthopedic and Cardiac Surgery Patients
Transfusion rates remain high in cardiac and orthopedic surgery and differ widely across physician practices in spite of growing knowledge that allogeneic blood transfusion (ABT) is associated with a risk of postoperative infection.
The Effect on Long-Term Survival of Erythrocyte Transfusion Given for Cardiac Valve Operations
Studies in patients undergoing coronary artery bypass grafting (CABG) have shown an increased long-term mortality rates associated with perioperative blood transfusions.
Less Is More In Blood Transfusion Study
A new study suggests that blood transfusions for hospitalized cardiac patients should be a last resort because they double the risk of infection and increase by four times the risk of death.
Blood Transfusions Double risk of infection for Heart Bypass Patients
Heart bypass patients who receive blood transfusions are twice as likely to develop an infection after their operation, a new study shows.
State of the Art Blood Management in Cardiac Surgery
Blood has been described as the most precious and personal substance in the world (1), and caregivers focused on cardiac surgery issues now know that the current direction today in cardiac surgery is to actively move away from transfusing donor “allogeneic” blood products, and towards improved methods of keeping and saving the patient’s own autologous blood.
Stabilized Infective Endocarditis and Altered Heparin Responsiveness During Cardiopulmonary Bypass
We investigated whether heparin responsiveness was still altered in stabilized IE patients undergoing cardiac surgery in a prospective, controlled trial.
Bivalirudin: An Alternative Anticoagulant (Video)
Craig Vocelka discusses Bivalirudin as an alternative anticoagulant for patients with Heparin-Induced Thrombocytopenia (22 minutes).
Tug of War: Blood Management Safety (Video)
Susan Englert brings insight into the role perfusionists can play as part of a comprehensive blood management program (21 minutes).
Individual Probability of Allogeneic Erythrocyte Transfusion in Elective Spine Surgery: The Predictive Model of Transfusion in Spine Surgery
The aim of this study was to generate a score based on preoperative characteristics and predictive of the individual probability of allogeneic erythrocyte transfusion in patients undergoing elective thoracolumbar spine surgery.