Category: Blood Management

The obligatory hemodilution resulting from crystalloid priming of the cardiopulmonary bypass circuit represents a major risk factor for blood transfusion in cardiac operations. We therefore examined whether retrograde autologous priming of the bypass circuit would result in decreased hemodilution and red cell transfusion.

In a prospective study, 60 patients posted for coronary artery bypass graft (CABG) surgery on cardiopulmonary bypass (CPB) were assigned to 2 groups of 30 each. (group A =combination of acute normovolaemic haemodilution (ANH) and retrograde autologous priming (RAP), group B=control). The aim was to investigate whether retrograde autologous priming reduces haemoditution as compared to control cases.

Retrograde autologous priming (RAP) is a blood conservation technique used to limit the severity of hemodilution during cardiopulmonary bypass and reduce perioperative transfusions. The aim of this investigation was to examine the safety of RAP and to determine the effect of RAP on adverse outcomes after cardiac surgery.

Haemodilution resulting from crystalloid priming of the cardiopulmonary bypass (CPB) circuit is one of the important reasons for blood transfusion in cardiac surgery, especially in patients with low body surface area (BSA).

Autologous priming of the extracorporeal circuit used in conjunction with ultrafiltration, pharmacologic manipulation, and cell salvage may decrease the need for blood transfusion in the pediatric cardiac surgical population.

Extreme haemodilution occurring with cardiopulmonary bypass imposes a primary risk factor for blood transfusion in small adult cardiac surgical patients. Priming of the cardiopulmonary bypass circuit with patients' own blood [retrograde autologous priming (RAP)] is a technique used to limit haemodilution and reduce transfusion requirements.

The purpose of this study was to determine which factors impact the ability to perform autologous priming (AP) of the extracorporeal circuit.

The aim of this study was to investigate the effect of retrograde autologous priming (RAP) of the cardiopulmonary bypass (CPB) circuit on cerebral oxygenation.

A literature review and meta-analysis were undertaken to assess the clinical effectiveness of retrograde autologous priming of the cardiopulmonary bypass circuit to reduce allogeneic packed red blood transfusions in adult cardiac surgery.

Cardiac surgery in Jehovah's Witnesses poses unique challenges. We have developed a comprehensive multimodality program for these patients and have obtained excellent results.

We hypothesize that washing red blood cells and platelets transfused to these patients will reduce postoperative transfusion-related immune modulation and inflammation.

Irradiation of blood weakens the cell membranes and results in an increase of lactate and potassium concentration.