Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma
In this preliminary uncontrolled case series of 5 critically ill patients with COVID-19 and ARDS, administration of convalescent plasma containing neutralizing antibody was followed by improvement in their clinical status.
Are We Close to Bioengineering a Human-Sized, Functional Heart?
The model ventricles can be evaluated with the same assays used in animal models and in clinical settings.
Heparin Dose and Point-of-Care Measurements of Hemostasis in Cardiac Surgery—Results of a Randomized Controlled Trial
Compared with a lower dose of heparin during CPB, a high dose of heparin had little effect on the point-of-care measurements of hemostasis, TEM, and MEA. Based on the similarity of platelet and coagulation activity assessments, the higher heparin dose does not appear to offer benefit during CPB.
Thrombin Generation and Bleeding in Cardiac Surgery: a Clinical Narrative Review
This narrative review discusses the role of thrombin generation in coagulation and bleeding in cardiac surgery, the laboratory methods for clinical detection of impaired thrombin generation, and the available hemostatic interventions that can be used to improve thrombin generation.
Clotting Time Results Are Not Interchangeable Between EXTEM and FIBTEM on Rotational Thromboelastometry
CyD shortens the onset of TG and clot formation, resulting in shorter CTFIBTEM than CTEXTEM.
Vitamin D and Postoperative Delirium After Coronary Artery Bypass Grafting: A Prospective Cohort Study
Preoperative severe vitamin D deficiency was associated with the occurrence of delirium after coronary artery bypass grafting surgery.
Contemporary Australian Priming Constituents for Adult Perfusion Centres: a Survey
Contemporary Australian priming practices show a marked level of conformity between units. Variation exists in the rationale for adding sodium bicarbonate, mannitol and albumin.
In Vitro Recovery of Sufentanil, Midazolam, Propofol, and Methylprednisolone in Pediatric Cardiopulmonary Bypass Systems
The present in vitro experiment with neonatal, infant, and pediatric CPB systems shows a variable recovery of routinely used drugs with significant differences between drugs, but not between system categories (with the exception of propofol).
Neuroprotective Effect of Low Mean Arterial Pressure on Postoperative Cognitive Deficit Attenuated by Prolonged Coronary Artery Bypass Time: A Meta-Analysis
The neuroprotective effect of low MAP on POCD was attenuated by the prolonged CPB time.
Effect and Safety of 4% Albumin in the Treatment of Cardiac Surgery Patients: Study Protocol for the Randomized, Double-Blind, Clinical ALBICS (ALBumin In Cardiac Surgery) Trial
The findings of this study will provide new evidence regarding efficacy and safety of albumin solution in adult patients undergoing cardiac surgery with CPB.
Hyperlactatemia during Cardiopulmonary Bypass: Risk Factors and Impact on Surgical Results with a Focus on the Long-Term Outcome
Correction of risk factors for hyperlactatemia, together with prompt detection and correction of this condition, may control complications and improve outcome.
Thermal Distribution, Physiological Effects and Toxicities of Extracorporeally Induced Whole‐Body Hyperthermia in a Pig Model
Fast induction of eWBH with homogenous thermal distribution is feasible in pigs using the Vithèr WBH device. Severe hemodynamic disturbances, rhabdomyolysis, and hyperkalemia were observed.