Relevant reading, listening or viewing – curated by the creator of Tiny Perfusion Letter, Luc Puis
Every week, we collect 10 or 20 articles from the peer-reviewed literature that we think will be of interest to the perfusionist community. Feel free to comment on the findings or suggest entries for the newsletter by emailing the Editor – Luc Puis.
The continuous search for biocompatible materials leads to new ways of coating the materials we use. In an ex-vivo model with pigs, a new liquid-impregnated surface promises to diminish protein adsorption and thrombus development. A different approach is the use of a copper-based metal-organic framework that releases nitric oxide in the blood, which was also tested in pigs (poor guys). So, very promising, but still a lot of work to do.
A big study in China compared high-dose with low-dose tranexamic acid and reached a modest reduction in allogeneic blood transfusion, also showing noninferiority regarding a composite primary safety endpoint consisting of 30-day mortality, seizure, kidney dysfunction, and thrombotic events.
An interesting study in Norway exposed pigs (them again!) to 25°C hypothermia and, after rewarming, found that the animals were in a state of hypercoagulation.
More hypercoagulation: a cardiac surgery team in the Netherlands had to triple their heparin dose to achieve an ACT of >400s. The patient previously had a COVID-19 diagnosis a month before, and this case sheds light on how COVID can interfere in our practice for a longer term than we might wish.
In new technologies and original research, we look at a new type of gas exchange device that uses the natural capillary network as a model (guess what: pigs were mentioned). Also, a systematic review and meta-analysis on how to reduce limb ischemia in peripheral cannulation for VA ECMO is always helpful. And lastly in this rubric, a big overview of what’s cooking in the targeted temperature management post-cardiac-arrest.
Finally, we have two articles that talk about non-technical skills for cardiothoracic surgeons (much appreciated!) and how machine-learning can help us in predicting outcomes in cardiac surgery. Enjoy the read!
Biocompatibility – Patient Blood Management
- In Vitro Hemocompatibility Screening of A Slippery Liquid Impregnated Surface Coating for Extracorporeal Organ Support Applications
- Development and Blood Compatibility of a Stable and Bioactive Metal-Organic Framework Composite Coating for Blood-Circulation Tubing
- Effect of High- vs Low-Dose Tranexamic Acid Infusion on Need for Red Blood Cell Transfusion and Adverse Events in Patients Undergoing Cardiac Surgery: The OPTIMAL Randomized Clinical Trial.
- Enhanced Blood Clotting After Rewarming from Experimental Hypothermia in an Intact Porcine Model
- Accuracy of Point-Of-Care Coagulation Testing During Cardiopulmonary Bypass in A Patient Post COVID-19 Infection
New Technology – Original Research
- The Microfluidic Artificial Lung: Mimicking Nature’s Blood Path Design to Solve The Biocompatibility Paradox
- Strategies to Reduce Limb Ischemia in Peripheral Venoarterial Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis
- Contemporary Targeted Temperature Management: Clinical Evidence and Controversies