Perioperative THR-184 and AKI after Cardiac Surgery
AKI after cardiac surgery is associated with mortality, prolonged hospital length of stay, use of dialysis, and subsequent CKD. We evaluated the effects of THR-184, a bone morphogenetic protein-7 agonist, in patients at high risk for AKI after cardiac surgery.
Acute Kidney Injury After Cardiac Surgery: Prevalence, Impact and Management Challenges
In this review, we explore the definition of cardiac surgery-associated acute kidney injury (CSA-AKI) and identify diverse mechanisms and risk factors contributing to the renal insult.
A Pilot Goal-Directed Perfusion Initiative Is Associated With Less Acute Kidney Injury After Cardiac Surgery
We sought to determine whether a pilot goal-directed perfusion initiative could reduce the incidence of acute kidney injury after cardiac surgery.
Optimizing Perioperative Blood and Coagulation Management During Cardiac Surgery
This article reviews the hemostasis disturbances in cardiac surgery with cardiopulmonary bypass and gives an overview of the most important patient blood management strategies.
Enhanced Activity by NKCC1 and Slc26a6 Mediates Acidic pH and Cl- Movement after Cardioplegia-Induced Arrest of db/db Diabetic Heart
Diabetic heart dysfunctions during cardiac surgeries have revealed several clinical problems associated with ion imbalance. However, the mechanism of ion imbalance mediated by cardioplegia and a diabetic heart is largely unclear.
Acute Kidney Injury after Cardiac Surgery: Risk Factors and Novel Biomarkers
Acute kidney injury (AKI) is a common and severe complication after cardiac surgery. Currently, a series of novel biomarkers have favored the assessment of AKI after cardiac surgery in addition to the conventional indicators.
Blood Utilization in Revision Versus First-Time Cardiac Surgery: An Update in the Era of Patient Blood Management
Relative to first-time (primary) cardiac surgery, revision cardiac surgery is associated with increased transfusion requirements, but studies comparing these cohorts were performed before patient blood management (PBM) and blood conservation measures were commonplace. The current study was performed as an update to determine if this finding is still evident in the PBM era.
Nature of Cardiac Rehabilitation Around the Globe
Cardiac rehabilitation (CR) is a clinically-effective but complex model of care. The purpose of this study was to characterize the nature of CR programs around the world, in relation to guideline recommendations, and compare this by World Health Organization (WHO) region.
Heart Valve Operations Associated With Reduced Risk Of Death From Mitral Valve Disease But Other Operations Associated With Increased Risk of Death: A National Population-Based Case-Control Study
This study analyzed the death risk from heart valve disease with respect to the frequency of heart valve operation and other operations in patients with mitral valve disease.
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly
Aspirin is a well-established therapy for the secondary prevention of cardiovascular events. However, its role in the primary prevention of cardiovascular disease is unclear, especially in older persons, who have an increased risk.
Toward Precision Policy — The Case of Cardiovascular Care
The U.S. health care system is in the midst of a transition toward delivery of high-value rather than volume-based health care.
Mechanical or Biologic Prostheses for Aortic-Valve and Mitral-Valve Replacement
In patients undergoing aortic-valve or mitral-valve replacement, either a mechanical or biologic prosthesis is used. Biologic prostheses have been increasingly favored despite limited evidence supporting this practice.