Extracts of Adipose Derived Stem Cells Slows Progression in the R6/2 Model of Huntington’s Disease
Stem cell transplantation has been investigated as a therapeutic strategy to treat the Huntington's disease (HD). Considering clinical feasibility and safety, injection of cell-free extracts of ASCs (ASCs-E) could be effective and safe strategy for HD patients, comparable to the stem cell therapy. Findings from our study provide possible strategy to inhibit HD progression and reasonable resources for treatment.
Decreased Erythrocyte Deformability After Transfusion and the Effects of Erythrocyte Storage Duration
The findings demonstrate that increased duration of erythrocyte storage is associated with decreased cell membrane deformability and that these changes are not readily reversible after transfusion.
Outcomes of Less Invasive J-Incision Approach to Aortic Valve Surgery
Within that portion of the spectrum of isolated aortic valve surgery where propensity matching was possible, minimally invasive aortic valve surgery had not only cosmetic advantages, but blood product use, respiratory, pain, and resource utilization advantages over full sternotomy, and no apparent detriments.
Noise Levels in Modern Operating Rooms During Surgery
This study consistently showed that noise in the operating room is louder during the critical anesthesia components of the case.
Establishing proof of concept: Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate may Improve Cartilage Repair Following Surgical Treatment for Osteochondral Lesions of the Talus
The basic science literature therefore establishes the proof of concept that biological adjuncts may improve cartilage repair when used in conjunction with reparative and replacement treatment strategies for osteochondral lesions of the talus.
In Vivo Comparison of the Bone Regeneration Capability of Human Bone Marrow Concentrates vs. Platelet-Rich Plasma
The objective of this study was to evaluate the effects of human BMAC and PRP in combination with β-tricalcium phosphate (β-TCP) on promoting initial bone augmentation in an immunodeficient mouse model.
Regenerate Augmentation with Bone Marrow Concentrate after Traumatic Bone Loss
The aim of this feasibility study was to investigate the potential of bone marrow aspiration concentrate (BMAC) for percutaneous regenerate augmentation to accelerate bony consolidation of the regenerate.
Platelet-Rich Plasma (PRP): An Adjuvant to Hasten Hamstring Muscle Recovery. A Randomized Controlled Trial Protocol
This study protocol proposes a rigorous and potential significant evaluation of PRP use for grade-2 hamstring injury.
Outcomes after Ultrasound-Guided Platelet-Rich Plasma Injections for Chronic Tendinopathy: A Multicenter, Retrospective Review
In this retrospective study, in which we evaluated administration of PRP for chronic tendinopathy, we found that the majority of patients reported a moderate (>50%) improvement in pain symptoms.
Platelet-Rich Plasma Versus Focused Shock Waves in the Treatment of Jumper’s Knee in Athletes
Therapeutic injections of PRP lead to better midterm clinical results compared with focused ESWT in the treatment of jumper's knee in athletes.
The Positive Effects of Different platelet-Rich Plasma Methods on Human Muscle, Bone, and Tendon Cells
The primary findings of this study suggest the application of different PRP separations may result in a potential beneficial effect on the clinically relevant target cells in vitro.
Platelet-Rich Plasma Application in the Management of Chronic Tendinopathies
Platelets release various cytokines and growth factors which promote angiogenesis, tissue remodeling, and wound healing. We made an extended literature review of the use of PRP in chronic tendinopathies: epicondylitis, rotator cuff, patellar and calcaneal tendinopathies, and plantar fasciitis.