Nanosecond Pulse Electric Field Activation of Platelet-Rich Plasma Reduces Myocardial Infarct Size and Improves Left Ventricular Mechanical Function in the Rabbit Heart
In the current study, we used the novel, nonchemical method of nanosecond pulsed electric fields (nsPEF) to investigate the efficiency of a protocol involving the in vivo treatment of the ischemic and reperfused heart and heart cells in culture with platelet-rich plasma (PRP).
Comparison between d901 Lilliput 1 and Kids d100 Neonatal Oxygenators: Toward Bypass Circuit Miniaturization
In this study, we describe our clinical experience comparing performance of two neonatal oxygenators.
Excessive Negative Venous Line Pressures and Increased Arterial Air Bubble Counts during Miniaturized Cardiopulmonary Bypass: An Experimental Study Comparing Miniaturized with Conventional Perfusion Systems
Despite the benefits of MCPB regarding systemic inflammatory response and haemolysis, this technique is associated with excessive negative venous line pressures
An Automated Method for Analysis of Microcirculation Videos for Accurate Assessment of Tissue Perfusion
The experimental algorithm automatically extracts microvascular network and quantitatively measures changes in the microcirculation
Direct Innominate Artery Cannulation for Antegrade Cerebral Perfusion in Neonates undergoing Arch Reconstruction
The purpose of the present study was to evaluate the flow measurements and safety of DC when compared with IC.
Pilot Alternating Treatment Design Study of the Splanchnic Metabolic Effects of Two Mean Arterial Pressure Targets during Cardiopulmonary Bypass
The arterial pressure target for optimal splanchnic function during cardiopulmonary bypass (CPB) is uncertain.
Antifibrinolytics in Cardiac Surgery
Cardiac surgery exerts a significant strain on the blood bank services and is a model example in which a multi-modal blood-conservation strategy is recommended.
Management of Massive Bleeding in 2013: Seven Questions and Answers
The management of massive bleeding has improved, thanks to high-quality blood components and new transfusion strategies. However, it remains controversial and, despite a huge body of literature, randomised control trials are still lacking.
Immediate Effects of Individualized Heparin and Protamine Management on Hemostatic Activation and Platelet Function in Adult Patients Undergoing Cardiac Surgery with Tranexamic Acid Antifibrinolytic Therapy
This randomized prospective study was initiated to clarify whether individualized heparin and protamine dosing has immediate effects on hemostatic activation and platelet function in adult cardiac surgery.
Assessment and Management of Massive Bleeding: Coagulation Assessment, Pharmacologic Strategies, and Transfusion Management
This review details the current knowledge in massive hemorrhage with regard to the pathophysiology and laboratory assessment of the coagulation disturbance, the role of plasma and platelet transfusion, the role of pharmaceutical strategies, and the clinical value of having a massive transfusion protocol.
Low Hemorrhage-Related Mortality in Trauma Patients in a Level I Trauma Center Employing Transfusion Packages and Early Thromboelastography-Directed Hemostatic Resuscitation with Plasma and Platelets
This was a prospective study of adult trauma patients admitted to a Level I trauma center. Demography, Injury Severity Score (ISS), transfusion therapy, and mortality were registered. Hemostatic resuscitation was based on a massive transfusion protocolencompassing transfusion packages and thromboelastography (TEG)-guided therapy.
Platelet Concentrates, from Whole Blood or Collected by Apheresis
The quality and characteristics of platelets during storage are affected by a number of factors, such as anticoagulant, centrifugation and processing after collection, and pre- or post storage pooling, but when comparing literature on the various methods, most differences balance out.