Clot Formation in Cardiopulmonary Bypass Circuit After Application of Factor XI Concentrate
This case highlights the challenges in the management of patients with FXI deficiency undergoing cardiac surgery and the need for a multidisciplinary approach. Caution is warranted when using FXI concentrate in this patient population.
PaO2 Greater than 300 mmHg Promotes an Inflammatory Response During Extracorporeal Circulation in a Rat Extracorporeal Membrane Oxygenation Model
These data demonstrate that it is better to avoid administration of too much oxygen during ECMO to attenuate lung injury linked to generation of superoxide and the systemic inflammatory response.
Impact of Mesenchymal Stromal Cell Delivery Through Cardiopulmonary Bypass on Postnatal Neurogenesis
MSC delivery through CPB has the potential to mitigate effects of CPB on neural stem/progenitor cells and to promote migration of neuroblasts. Further investigation is necessary to determine the long-term effect of MSC treatment during CPB on postnatal neurogenesis.
A Dual-Lumen Bicaval Cannula for Venovenous Extracorporeal Membrane Oxygenation
This cannula introduces design qualities that may offer advantages for acute respiratory failure requiring venovenous ECMO.
Are We Able to Dose Protamine Accurately Yet? A Review of the Protamine Conundrum
This review is seeking to capture the current thinking about protamine dosing after cessation of cardiopulmonary bypass.
ECMO as a Platform for Rapid Ammonia Removal in a Neonate With Multienzyme Urea Cycle Disorder
This case will add to the existing scant literature supporting the use of ECMO as a platform for rapid removal of serum ammonia.
Postoperative Complications Are Not Elevated in Well-Compensated ESRD Patients Undergoing Cardiac Surgery: End-Stage Renal Disease Cardiac Surgery Outcomes
Stable ESRD patients undergoing nonemergent surgery are not at increased risk of major postoperative complications when compared to those without ESRD. Well-compensated ESRD patients should not be excluded from surgical consideration.
Association Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical Outcomes
This study suggests that the 72-hour period immediately after AKI distinguishes the risk of clinically important kidney-specific long-term outcomes.
Treating Delirium in the Intensive Care Unit: No Easy Answers
This is an invited expert review commentary on delirium treatment in the ICU.
Characteristics, Treatment, Outcomes and Cause of Death of Invasively Ventilated Patients with COVID-19 ARDS in Milan, Italy
Despite multiple advanced critical care interventions, COVID-19 ARDS was associated with prolonged ventilation and high short term mortality. Older age and pre-admission hypertension were key mortality risk factors.
NIH COVID-19 Treatment Guidelines
These Treatment Guidelines have been developed to inform clinicians how to care for patients with COVID-19.
Incidence of Thrombotic Complications in Critically Ill ICU Patients with COVID-19
Our findings reinforce the recommendation to strictly apply pharmacological thrombosis prophylaxis in all COVID-19 patients admitted to the ICU, and are strongly suggestive of increasing the prophylaxis towards high-prophylactic doses, even in the absence of randomized evidence.