Development of Persistent Opioid Use After Cardiac Surgery
Centers must adopt protocols to increase patient education and limit opioid prescriptions after discharge.
Supplemental Cardioplegia During Donor Heart Implantation: A Systematic Review and Meta-Analysis.
Administration of supplemental cardioplegia may be associated with a reduction in organ ischemic injury and shorter intensive care stay as well as improvement in early survival after transplantation.
Thrombosis and Coagulopathy in COVID‐19: An Illustrated Review
There appear to be high rates of venous thromboembolism and also, what has been poorly described before in acute lung injury, a high rate of pulmonary immunothrombosis (thrombosis secondary to inflammation).
Is a “Cytokine Storm” Relevant to COVID-19?
A critical evaluation of the term cytokine storm and its relevance to COVID-19 is warranted.
The role of ECMO in COVID-19: Can it Provide Rescue Therapy in Those Who Are Critically Ill?
Our understanding of COVID‐19 is ever‐changing and the need for intensive care beds is rising, which means that ECMO will surely play a key role in the near future.
Severe Impairment of Microcirculatory Perfused Vessel Density Is Associated With Postoperative Lactate and Acute Organ Injury After Cardiac Surgery
In patients undergoing cardiac surgery, there was a significant decrease in postoperative microcirculatory convective blood flow and diffusive capacity during early postoperative resuscitation.
Hyperlactatemia of Dialysis-Dependent Patients After Cardiac Surgery Impacts on In-Hospital Mortality: A Two-Center Retrospective Study
In dialysis-dependent patients after cardiac surgery, the early-onset of a maximum arterial lactate concentration of > 4.5 mmol/L was significantly associated with in-hospital mortality.
Toll-like Receptor 9 and the Inflammatory Response to Surgical Trauma and Cardiopulmonary Bypass
CPB, surgical trauma and ischemic perfusion injury trigger the release of circulating mtDNA that activates TLR-9, in turn stimulating a release of IL-6. Therefore, TLR-9 antagonists may attenuate this response and may provide a future therapeutic target whereby the systemic inflammatory response to cardiac surgery may be manipulated to improve clinical outcomes.
Effect of Pulsatile Cardiopulmonary Bypass in Adult Heart Surgery
Findings of this study do not support the superiority of pulsatile flow pattern during CPB, in terms of cerebral oxygen saturation or postoperative mortality/morbidity.
Preoperative Vitamin D Level is Associated with Postoperative Delirium After Cardiac Surgery in Patients Over 65 Years of Age
Vitamin D deficiency exacerbates delirium after coronary artery bypass surgery with cardiopulmonary bypass.
Normoxic Re-Oxygenation Ameliorates End-Organ Injury After Cardiopulmonary Bypass
Normoxic reperfusion ameliorates cardiac, renal and neural injury compared with hyperoxic reperfusion in an in vivo animal model of CPB and cardioplegic arrest. This protective effect of normoxic reperfusion may be due to a reduction in signaling pathways for OS, inflammation, and apoptosis.
Anticoagulation Management During Pulmonary Endarterectomy With Cardiopulmonary Bypass and Deep Hypothermic Circulatory Arrest
This study shows a wide variation in individual heparin sensitivity in patients undergoing pulmonary endarterectomy with deep hypothermic circulatory arrest.