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Gene Therapy during Cardiac Surgery: Role of Surgical Technique to Minimize Collateral Organ Gene Expression
Effective gene therapy for heart failure has not yet been achieved clinically.
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Ministernotomy Versus Conventional Sternotomy for Aortic Valve Replacement: Matched Propensity Score Analysis of 808 Patients
The proportion of minimally invasive approaches is rising in cardiac surgery, in part driven by increasing patient demand. This study aimed to perform a risk-adjusted comparison of mortality, rate of stroke and perioperative morbidity of aortic valve replacement (AVR) conducted through either partial ministernotomy or conventional sternotomy.
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Appropriate Clinical Trial Registration Is the Key to Transparent Reporting and Publication
In summary, since the advent of the ClinicalTrials.gov platform, the importance of trial registration has been recognized gradually but consistently throughout the globe. However, challenges remain, including the reluctance to participate on the part of pharmaceutical companies and a mindset among the individual researchers that registration is onerous and may result in the report of insignificant primary outcomes.
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