Transfusion in Elective Aortic Root Replacement: Analysis of the STS Adult Cardiac Surgery Database
Elective aortic root replacement can be performed with acceptable requirements for blood products. Composite root replacement has a greater likelihood of transfusion than does a valve-sparing procedure.
Mild AKI Is Associated with Mortality of Patients Who Underwent Cardiopulmonary Bypass Surgery
AKI stage I is the most common form of AKI and it is independently related to all-cause mortality in patients who underwent cardiovascular surgery with cardiopulmonary bypass.
Interaction of Heparin and Protamine in Presence of Overdosage: In Vitro Study
We reconfirmed that the ROTEM device enables discrimination of the effects heparin and protamine on coagulation and detection of the coagulation-impairing effects of protamine overdosage. Furthermore, we were able to show a positive effect on coagulation times by heparin in the presence of protamine overdosage.
ISTH DIC Subcommittee Communication on Anticoagulation In COVID-19
Although the current evidence is still insufficient, we provide a pragmatic approach to anticoagulation in COVID‐19, but stress the need for further trials in this area.
Analysis of Mirrored Psychophysiological Change of Cardiac Surgery Team Members During Open Surgery
In this pilot study, mirrored physiological responses representing peaks in cognitive workload were observed uncommonly across dyads of cardiac surgery team members (1.73 peaks/case on average). Almost half of these occurred during the most technically demanding phases of cardiac surgery, which may underpin teamwork quality.
A Comparative Analysis of Four Activated Clotting Time Measurement Devices in Cardiac Surgery with Cardiopulmonary Bypass
Careful validation must be undertaken when adopting a different method as decision limits would be affected. Clinicians should also be cautious using ACT as the only indicator for full heparin reversal.
COVID-19 Associated Hypercoagulability Manifestations, Mechanisms, and Management
In this narrative review, we summarize clinical manifestations of COVID-19, mechanisms, monitoring considerations, and anticoagulant therapy. We also review unique considerations for COVID-19 patients who are on extracorporeal membrane oxygenation.
Hypoxic Storage of Red Blood Cells Improves Metabolism and Post-Transfusion Recovery
Hypoxic storage improves energy and redox metabolism of stored RBCs, which results in improved posttransfusion recoveries in healthy autologous recipients—a Food and Drug Administration gold standard of stored blood quality. In addition, we identified candidate metabolic predictors of PTR for RBCs stored under standard and hypoxic conditions.
Factors Associated with Errors in The Heparin Dose Response Test: Recommendations to Improve Individualized Heparin Management in Cardiopulmonary Bypass
The mACT can be substantially different from eACT. The accuracy of the HDR test appears to be dependent upon bACT, slope, and CHC. Based on our analysis, we provide several recommendations and a flow chart to improve the quality of individualized heparin management on CPB.
Platelet Function Testing in Patients on Antiplatelet Therapy before Cardiac Surgery
Although preoperative P2Y12 receptor inhibitor therapy may reduce ischemic events, late preoperative exposure to P2Y12 receptor inhibitors increases the risk of surgery-associated bleeding and reoperation for bleeding.
Impact Of 6% Balanced Hydroxyethyl Starch Following Cardiopulmonary Bypass on Renal Function: A Retrospective Study
The moderate dose administration of HES (≥20 ml/kg) in the postoperative period following cardiac surgery might be associated with the risk of AKI. However, it was not associated with serious adverse outcomes such as new RRT or mortality. Further randomized controlled studies are needed to validate study results.
Anti-Xa Versus Time-Guided Anticoagulation Strategies in Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis
In this meta-analysis of observational studies of patients on ECMO, an anti-Xa-based anticoagulation strategy, when compared to a time-based strategy, was associated with fewer bleeding events and mortality rate, without an increase in thrombotic events.