Bivalirudin-Based Versus Conventional Heparin Anticoagulation for Postcardiotomy Extracorporeal Membrane Oxygenation
The present study is a retrospective comparison of the conventional heparin-based anticoagulation protocol with a bivalirudin-based, heparin-free protocol. Endpoints of this study are blood loss, allogeneic blood product use, and costs during the ECMO procedure.
Impact of Cell Salvage During Cardiac Surgery on the Thrombelastomeric Coagulation Profile: A Pilot Study
Intraoperative cell salvage of the cardiopulmonary bypass residual volume can dilute platelets and coagulation factors. This is a report of a randomised control trial of 20 patients undergoing coronary bypass surgery.
Thrombelastography Change after Bridging to Left Ventricular Assist Device From Extracorporeal Membrane Oxygenation Patients
Coagulopathy of patients with VAD improved after bridging from ECMO, which can be attributed to improved coagulation factor and platelet function. Thus, bleeding complications are reduced.
A Randomized Prospective Analysis of Alteration of Hemostatic Function in Patients Receiving Tranexamic Acid and Hydroxyethyl Starch Undergoing Off Pump Coronary Artery Bypass Surgery
Postoperative hemorrhagic complications is still one of the major problems in cardiac surgeries. It may be caused by surgical issues, coagulopathy caused by the side effects of the intravenous fluids administered to produce plasma volume expansion such as hydroxyl ethyl starch (HES).
Platelet Mapping as Part of Modified Thromboelastography (TEG) in Patients Undergoing Cardiac Surgery and Cardiopulmonary Bypass
The platelet-mapping assay of the thromboelastograph was used to measure platelet aggregation and to examine the effect of cardiopulmonary bypass on multiple platelet receptors and the role of altered receptor activity in postoperative bleeding.
Monitoring Patients at Risk of Massive Transfusion with Thrombelastography or Thromboelastometry: A Systematic Review
Thrombelastography (TEG) and Thrombelastometry (ROTEM) are viscoelastic whole-blood assays evaluating the haemostatic capacity of blood. These devices are used in algorithms to guide transfusion of haemostatic blood components.
A Method for Anticoagulation of Children on Mechanical Circulatory Support
We describe an anticoagulation protocol based upon TEG and platelet aggregation studies and using heparin, aspirin, and dipyridamole. Adequate anticoagulation is more difficult in children. However, 71% of the patients in our study survived long term.
Left Ventricular Assist Device Support and Myocardial Recovery in Recent Onset Cardiomyopathy
Left ventricular assist device (LVAD) support as bridge to recovery (BTR) is uncommon for subjects with chronic heart failure. Myocardial recovery is more evident in recent onset nonischemic cardiomyopathy (ROCM); however, the prevalence of BTR in this subset has not been addressed.
Device Exchange After Primary Left Ventricular Assist Device Implantation: Indications and Outcomes
Patients are being supported for longer periods with implantable left ventricular assist devices (LVADs) owing to longer transplantation wait times and approval of LVADs for destination therapy. This comes with an increased potential need for device exchange when complications arise. There are few data examining this patient population.
Development of a Novel Echocardiography Ramp Test for Speed Optimization and Diagnosis of Device Thrombosis in Continuous-Flow Left Ventricular Assist Devices: The Columbia Ramp Study
Ramp tests facilitate optimal speed changes and device malfunction detection and may be used to monitor the effects of therapeutic interventions and need for surgical intervention in CF-LVAD patients.
Nutrition Assessment in Advanced Heart Failure Patients Evaluated for Ventricular Assist Devices or Cardiac Transplantation
The state of undernutrition is an independent predictor of mortality in patients with AHF. Early recognition of undernutrition through use of the MNA may affect the long-term prognosis of these patients by enabling early intervention.
Optimization of Leukocyte Concentration in Platelet-Rich Plasma for the Treatment of Tendinopathy
The optimum composition of PRP for the treatment of tendinopathy has not been directly investigated. Persistent inflammation results in inferior repair with scar tissue. The present study indicates that in an animal model, WBC in PRP contributes to inflammatory cytokine production. Therefore, leukocyte-reduced PRP may be the optimum preparation to stimulate superior healing without scar tissue formation.