Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)
Myocardial injury is significantly associated with fatal outcome of COVID-19, while the prognosis of patients with underlying CVD but without myocardial injury is relatively favorable.
Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma
In this preliminary uncontrolled case series of 5 critically ill patients with COVID-19 and ARDS, administration of convalescent plasma containing neutralizing antibody was followed by improvement in their clinical status.
Outcome Impact of Different Tranexamic Acid Regimens in Cardiac Surgery with Cardiopulmonary Bypass (OPTIMAL): Rationale, Design, and Study Protocol of a Multicenter Randomized Controlled Trial
The study is designed to identify a TxA dose with maximal efficacy and minimal complications. We hypothesize that the high dose has superior efficacy and noninferior safety to the low dose.
Update on Extracorporeal Carbon Dioxide Removal: a Comprehensive Review on Principles, Indications, Efficiency, and Complications
Extracorporeal carbon dioxide removal means the removal of carbon dioxide from the blood across a gas exchange membrane without substantially improving oxygenation.
Large-Vessel Occlusion Stroke after Cardiothoracic Surgery: Expanding Time Windows Offer New Salvage Opportunities
LVO complicates a small proportion of patients after CTS and may be more likely with prolonged aortic crossclamp and cardiac bypass times.
Are We Close to Bioengineering a Human-Sized, Functional Heart?
The model ventricles can be evaluated with the same assays used in animal models and in clinical settings.
Influence of a High-Intensity Staffing Model in a Cardiac Surgery Intensive Care Unit on Postoperative Clinical Outcomes
High-intensity staffing model during daytime hours by cardiac surgery intensivists significantly improved ICU-related outcomes. However, high-intensity staffing did not affect early mortality after cardiac surgery.
Results from an Enhanced Recovery Program for Cardiac Surgery
There is value in developing phase-specific enhanced recovery programs guidelines, which improve rates of early extubation and affect the duration of stay after cardiac surgery.
Does the Full-Time Presence of an Intensivist Lead to Better Outcomes in the Cardiac Surgical Intensive Care Unit?
In this large cohort of patients admitted to a dedicated adult cardiac surgery intensive care unit, 24-hour intensivist coverage was associated with reduced mortality among patients with an expected operative mortality 5% or greater.
Heparin Dose and Point-of-Care Measurements of Hemostasis in Cardiac Surgery—Results of a Randomized Controlled Trial
Compared with a lower dose of heparin during CPB, a high dose of heparin had little effect on the point-of-care measurements of hemostasis, TEM, and MEA. Based on the similarity of platelet and coagulation activity assessments, the higher heparin dose does not appear to offer benefit during CPB.
Thrombin Generation and Bleeding in Cardiac Surgery: a Clinical Narrative Review
This narrative review discusses the role of thrombin generation in coagulation and bleeding in cardiac surgery, the laboratory methods for clinical detection of impaired thrombin generation, and the available hemostatic interventions that can be used to improve thrombin generation.
Clotting Time Results Are Not Interchangeable Between EXTEM and FIBTEM on Rotational Thromboelastometry
CyD shortens the onset of TG and clot formation, resulting in shorter CTFIBTEM than CTEXTEM.