The Nondepolarizing, Normokalemic Cardioplegia Formulation Adenosine-Lidocaine (Adenocaine) Exerts Anti-Neutrophil Effects by Synergistic Actions of its Components
Adenocaine suppresses multiple PMN functions including O(2)(-) generation, adhesion molecule expression, PMN adherence, and transmigration. In addition to inducing nondepolarized arrest, adenocaine cardioplegia may exert cardioprotection by inhibiting PMN-mediated inflammatory responses.
