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Serum Metabolic Profile of Postoperative Acute Kidney Injury Following Infant Cardiac Surgery with Cardiopulmonary Bypass
Moderate-to-severe AKI after infant cardiac surgery is associated with changes in the serum metabolome, including prominent changes to purine, methionine, and kynurenine/nicotinamide metabolism. A portion of infants with mild AKI demonstrated similar metabolic changes, suggesting a potential role for metabolic analysis in the evaluation of lower stage injury.
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Dextran Sulfate as a Leukocyte–Endothelium Adhesion Molecule Inhibitor of Lung Injury in Pediatric Open-Heart Surgery
To prevent this injury, we used a leukocyte–endothelial cell adhesion molecule blocking agent, dextran sulfate, in a clinical setting.
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Use of Laboratory Testing for Prediction of Postoperative Bleeding Volume in Cardiovascular Surgery
These results suggest that several clinical and routine laboratory parameters of coagulation were individually associated with bleeding volume during cardiovascular surgery. Determining the patterns of coagulopathy may potentially help guide transfusion during cardiovascular surgery.
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