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A Novel Antidote-Controlled Anticoagulant Reduces Thrombin Generation and Inflammation and Improves Cardiac Function in Cardiopulmonary Bypass Surgery
Here we demonstrate that an anticoagulant aptamer-antidote pair targeting factor IXa can replace heparin and protamine in a porcine CPB model and also limit the adverse effects on thrombin generation, inflammation, and cardiac physiology associated with heparin and protamine use.
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Haematocrit is Invalid for Estimating Red Cell Volume: A Prospective Study in Male Volunteers
Although haematocrit and haemoglobin value are concentrations, they are commonly used to guide clinical decisions involving red cell and plasma volumes. A study challenging this convention systematically co-determined and compared these measures.
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Toward Precision Policy — The Case of Cardiovascular Care
The U.S. health care system is in the midst of a transition toward delivery of high-value rather than volume-based health care.
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