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Validation of the Relationship Between Coagulopathy and Localization of Hydroxyethyl Starch on the Vascular Endothelium in A Rat Hemodilution Model
HES was shown to cover the endothelium, possibly due to its high shear viscosity, and this mechanism potentially acted to protect, rather than damage, the endothelium and glycocalyx. However, this covering effect may be the cause of coagulopathy due to inhibition of von Willebrand factor secretion from the endothelium.
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Different Dose Regimes and Administration Methods of Tranexamic Acid in Cardiac Surgery: A Meta-Analysis of Randomized Trials
The efficacy of tranexamic acid (TXA) to reduce perioperative blood loss and allogeneic blood transfusion in cardiacsurgeries has been proved in previous studies, but its adverse effects especially seizure has always been a problem of concern.
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Preoperative Statin Therapy is Associated with Lower Requirement of Renal Replacement Therapy in Patients undergoing Cardiac Surgery: A Meta-Analysis of Observational Studies
Patients undergoing CABG might derive benefit from preoperative statin therapy in terms of reducing the need for postoperative renal replacement therapy and mortality.
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