Hemoglobin-Driven Pathophysiology is an in Vivo Consequence of the Red Blood Cell Storage Lesion that can be Attenuated in Guinea Pigs by Haptoglobin Therapy
Pathologies observed after transfusion with old blood, together with the favorable response to Hp supplementation, allowed us to define the in vivo consequences of the rbc storage lesion as storage-related posttransfusion hemolysis producing Hb-driven pathophysiology. Hb sequestration by Hp might therefore be a therapeutic modality for enhancing transfusion safety in severely ill or massively transfused patients.
