Elevated Pulmonary Artery Systolic Pressures are Associated with a Lower Risk of Atrial Fibrillation following Lung Transplantation

BACKGROUND:

Atrial fibrillation (AF) is common after open-chest procedures, but the etiology remains poorly understood. Lung transplant procedures allow for the study of novel contributing factors.

METHODS:

Records of lung transplant procedures performed at a single center between 2002 and 2009 were reviewed.

RESULTS:

Of 174 patients, 27 (16%) had AF a median 6days post-surgery. Post-operative AF patients less often had right ventricular hypertrophy (RVH) by either electrocardiogram (0 versus 14%, P=.042) or echocardiography (19% versus 47%, P=.006), and had lower pulmonary artery systolic pressures (PASP) (39±12 versus 51±22, P=.005). After multivariable adjustment, every 10-mm Hg increase in PASP was associated with a 31% reduction in the odds of post-operative AF (OR 0.69, 95% CI 0.49-0.98, P=.035). A higher pulmonary pressure was the only predictor independently associated with less post-operative AF.

CONCLUSIONS:

Higher PASP was associated with a lower risk of AF after lung transplantation.