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Complement Activation on the Surface of Cell-Derived Microparticles During Cardiac Surgery With Cardiopulmonary Bypass – Is Retransfusion of Pericardial Blood Harmful?
To investigate whether cell-derived microparticles play a role in complement activation in pericardial blood of patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) and whether microparticles in pericardial blood contribute to systemic complement activation upon retransfusion.
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The Susceptibility of the Aortic Root: Porcine Aortic Rupture Testing Under Cardiopulmonary Bypass
This unique porcine model shows that the aortic root is most susceptible to failure at high continuous aortic pressures, supported histologically by different changes in collagen content and subtypes in the aortic root. With further analysis, this information could guide management of the aortic root in disease.
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Xenogeneic Cross-Circulation for Extracorporeal Recovery of Injured Human Lungs
Our findings suggest that cross-circulation can serve as a complementary approach to clinical EVLP to recover injured donor lungs that could not otherwise be utilized for transplantation, as well as a translational research platform for immunomodulation and advanced organ bioengineering.
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