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Degradation of the Endothelial Glycocalyx Contributes to Metabolic Acidosis in Children Following Cardiopulmonary Bypass Surgery
Our data show that metabolic acidosis (increased strong ion gap) is associated with plasma concentration of heparan sulfate, a negatively charged glycosaminoglycan cleaved from the endothelial glycocalyx during cardiopulmonary bypass. In addition, cleavage of heparan sulfate was associated with renal dysfunction, capillary leak, and global markers of cardiovascular dysfunction. These data highlight the importance of designing translational therapies to protect the glycocalyx in cardiopulmonary bypass.
Activation of Neutrophils and Monocytes by a Leukocyte-Depleting Filter Used Throughout Cardiopulmonary Bypass
We studied the effects of a leukocyte-depleting filter on phagocyte activation during cardiopulmonary bypass.
A 0.6-Protamine/Heparin Ratio in Cardiac Surgery is Associated with Decreased Transfusion of Blood Products
A 0.6/1-protamine/heparin ratio after weaning from CPB is associated with a significantly reduced 12-h postoperative blood loss and blood components transfusion.